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7x73

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'''Unreleased structure'''
 
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The entry 7x73 is ON HOLD
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==Structure of G9a in complex with RK-701==
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<StructureSection load='7x73' size='340' side='right'caption='[[7x73]], [[Resolution|resolution]] 1.49&Aring;' scene=''>
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Authors: Niwa, H., Shirai, F., Sato, S., Nishigaya, Y., Shirouzu, M., Umehara, T.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7x73]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7X73 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7X73 FirstGlance]. <br>
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Description: A structure of an enzyme in complex with compound 701
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.49&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=J26:N-[(2S)-1-[(4-cyanophenyl)amino]-4-cyclopropyl-1-oxidanylidene-butan-2-yl]-3,6,6-trimethyl-4-oxidanylidene-5,7-dihydro-1H-indole-2-carboxamide'>J26</scene>, <scene name='pdbligand=SFG:SINEFUNGIN'>SFG</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Nishigaya, Y]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7x73 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7x73 OCA], [https://pdbe.org/7x73 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7x73 RCSB], [https://www.ebi.ac.uk/pdbsum/7x73 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7x73 ProSAT]</span></td></tr>
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[[Category: Shirai, F]]
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</table>
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[[Category: Niwa, H]]
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== Function ==
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[[Category: Shirouzu, M]]
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[https://www.uniprot.org/uniprot/EHMT2_HUMAN EHMT2_HUMAN] Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself.<ref>PMID:8457211</ref> <ref>PMID:11316813</ref> <ref>PMID:18438403</ref> <ref>PMID:20118233</ref> <ref>PMID:22387026</ref>
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[[Category: Sato, S]]
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== References ==
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[[Category: Umehara, T]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Nishigaya Y]]
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[[Category: Niwa H]]
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[[Category: Sato S]]
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[[Category: Shirai F]]
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[[Category: Shirouzu M]]
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[[Category: Umehara T]]

Current revision

Structure of G9a in complex with RK-701

PDB ID 7x73

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OCA

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