7x83

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: '''Unreleased structure''' The entry 7x83 is ON HOLD Authors: Xia, W.C., Zhao, Q.Y., Fan, Y., Sun, Y.P., Tao, Y.Q., Liu, C. Description: Cryo-EM structure of the TMEM106B fibril from n...)
Current revision (11:44, 23 October 2024) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 7x83 is ON HOLD
+
==Cryo-EM structure of the TMEM106B fibril from normal elder==
-
 
+
<StructureSection load='7x83' size='340' side='right'caption='[[7x83]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
-
Authors: Xia, W.C., Zhao, Q.Y., Fan, Y., Sun, Y.P., Tao, Y.Q., Liu, C.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[7x83]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7X83 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7X83 FirstGlance]. <br>
-
Description: Cryo-EM structure of the TMEM106B fibril from normal elder
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7x83 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7x83 OCA], [https://pdbe.org/7x83 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7x83 RCSB], [https://www.ebi.ac.uk/pdbsum/7x83 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7x83 ProSAT]</span></td></tr>
-
[[Category: Sun, Y.P]]
+
</table>
-
[[Category: Tao, Y.Q]]
+
== Disease ==
-
[[Category: Liu, C]]
+
[https://www.uniprot.org/uniprot/T106B_HUMAN T106B_HUMAN] Progressive non-fluent aphasia;Semantic dementia;Behavioral variant of frontotemporal dementia. The gene represented in this entry acts as a disease modifier. Risk alleles confer genetic susceptibility by increasing gene expression (PubMed:20154673, PubMed:21178100). Increased expression may be the result of down-regulation of microRNA miR-132 and miR-212, that repress TMEM106B expression (PubMed:22895706). Thr-185 is a risk allele associated with lower GRN protein levels and early age at onset in GRN UP-FTD mutation carriers: it presents slower protein degradation that leads to higher steady-state TMEM106B levels, leading to alterations in the intracellular versus extracellular partitioning of GRN (PubMed:23742080).<ref>PMID:20154673</ref> <ref>PMID:21178100</ref> <ref>PMID:22895706</ref> <ref>PMID:23742080</ref> The gene represented in this entry acts as a disease modifier. The disease may be caused by variants affecting the gene represented in this entry.
-
[[Category: Xia, W.C]]
+
== Function ==
-
[[Category: Fan, Y]]
+
[https://www.uniprot.org/uniprot/T106B_HUMAN T106B_HUMAN] Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with MAP6. May act by inhibiting retrograde transport of lysosomes along dendrites. Required for dendrite branching.<ref>PMID:23136129</ref> <ref>PMID:24357581</ref>
-
[[Category: Zhao, Q.Y]]
+
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Fan Y]]
 +
[[Category: Liu C]]
 +
[[Category: Sun YP]]
 +
[[Category: Tao YQ]]
 +
[[Category: Xia WC]]
 +
[[Category: Zhao QY]]

Current revision

Cryo-EM structure of the TMEM106B fibril from normal elder

PDB ID 7x83

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/7x83"
Personal tools