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7wi6
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==Cryo-EM structure of LY341495/NAM-bound mGlu3== | ==Cryo-EM structure of LY341495/NAM-bound mGlu3== | ||
| - | <StructureSection load='7wi6' size='340' side='right'caption='[[7wi6]]' scene=''> | + | <StructureSection load='7wi6' size='340' side='right'caption='[[7wi6]], [[Resolution|resolution]] 3.71Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WI6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WI6 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7wi6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WI6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WI6 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wi6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wi6 OCA], [https://pdbe.org/7wi6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wi6 RCSB], [https://www.ebi.ac.uk/pdbsum/7wi6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wi6 ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=Z99:2-[(1S,2S)-2-CARBOXYCYCLOPROPYL]-3-(9H-XANTHEN-9-YL)-D-ALANINE'>Z99</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wi6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wi6 OCA], [https://pdbe.org/7wi6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wi6 RCSB], [https://www.ebi.ac.uk/pdbsum/7wi6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wi6 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/GRM3_HUMAN GRM3_HUMAN]] G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.<ref>PMID:8840013</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Fang W]] | [[Category: Fang W]] | ||
Current revision
Cryo-EM structure of LY341495/NAM-bound mGlu3
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