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3gur

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Current revision (15:44, 1 November 2023) (edit) (undo)
 
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<StructureSection load='3gur' size='340' side='right'caption='[[3gur]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='3gur' size='340' side='right'caption='[[3gur]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3gur]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GUR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GUR FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3gur]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GUR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GUR FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BYG:L-GAMMA-GLUTAMYL-S-{(4R)-4-[(6-HYDROXYHEXYL)SULFANYL]-7-NITRO-4,5-DIHYDRO-2,1,3-BENZOXADIAZOL-4-YL}-L-CYSTEINYLGLYCINE'>BYG</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3gus|3gus]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BYG:L-GAMMA-GLUTAMYL-S-{(4R)-4-[(6-HYDROXYHEXYL)SULFANYL]-7-NITRO-4,5-DIHYDRO-2,1,3-BENZOXADIAZOL-4-YL}-L-CYSTEINYLGLYCINE'>BYG</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gur OCA], [https://pdbe.org/3gur PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gur RCSB], [https://www.ebi.ac.uk/pdbsum/3gur PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gur ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gur OCA], [https://pdbe.org/3gur PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gur RCSB], [https://www.ebi.ac.uk/pdbsum/3gur PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gur ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/GSTM2_HUMAN GSTM2_HUMAN]] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.<ref>PMID:16549767</ref>
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[https://www.uniprot.org/uniprot/GSTM2_HUMAN GSTM2_HUMAN] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.<ref>PMID:16549767</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Glutathione transferase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Caccuri, A M]]
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[[Category: Caccuri AM]]
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[[Category: Federici, G]]
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[[Category: Di Matteo A]]
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[[Category: Federici, L]]
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[[Category: Federici G]]
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[[Category: Matteo, A Di]]
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[[Category: Federici L]]
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[[Category: Scaloni, F]]
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[[Category: Lo Sterzo C]]
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[[Category: Sterzo, C Lo]]
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[[Category: Scaloni F]]
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[[Category: Gstm2-2-inhibitor complex]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

Crystal Structure of mu class glutathione S-transferase (GSTM2-2) in complex with glutathione and 6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX)

PDB ID 3gur

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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