3gyu

<table><tr><td colspan='2'>[[3gyu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Strer Strer]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GYU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GYU FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DL7:(5BETA,14BETA,17ALPHA,25R)-3-OXOCHOLEST-7-EN-26-OIC+ACID'>DL7</scene></td></tr>

<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>

<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3gyt|3gyt]]</div></td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">daf-12 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6248 STRER])</td></tr>

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== Publication Abstract from PubMed ==

Nematode parasitism is a worldwide health problem resulting in malnutrition and morbidity in over 1 billion people. The molecular mechanisms governing infection are poorly understood. Here, we report that an evolutionarily conserved nuclear hormone receptor signaling pathway governs development of the stage 3 infective larvae (iL3) in several nematode parasites, including Strongyloides stercoralis, Ancylostoma spp., and Necator americanus. As in the free-living Caenorhabditis elegans, steroid hormone-like dafachronic acids induced recovery of the dauer-like iL3 in parasitic nematodes by activating orthologs of the nuclear receptor DAF-12. Moreover, administration of dafachronic acid markedly reduced the pathogenic iL3 population in S. stercoralis, indicating the potential use of DAF-12 ligands to treat disseminated strongyloidiasis. To understand the pharmacology of targeting DAF-12, we solved the 3-dimensional structure of the S. stercoralis DAF-12 ligand-binding domain cocrystallized with dafachronic acids. These results reveal the molecular basis for DAF-12 ligand binding and identify nuclear receptors as unique therapeutic targets in parasitic nematodes.

Identification of the nuclear receptor DAF-12 as a therapeutic target in parasitic nematodes.,Wang Z, Zhou XE, Motola DL, Gao X, Suino-Powell K, Conneely A, Ogata C, Sharma KK, Auchus RJ, Lok JB, Hawdon JM, Kliewer SA, Xu HE, Mangelsdorf DJ Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9138-43. Epub 2009 Jun 2. PMID:19497877<ref>PMID:19497877</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 3gyu" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Strer]]

[[Category: Auchus, R J]]

[[Category: Conneely, A]]

[[Category: Kliewer, S A]]

[[Category: Mangelsdorf, D J]]

[[Category: Motola, D L]]

[[Category: Ogata, C]]

[[Category: Sharma, K K]]

[[Category: Suino-Powell, K]]

[[Category: Wang, Z]]

[[Category: Xu, H E]]

[[Category: Zhou, X E]]

[[Category: Zinc-finger]]