Serine/threonine protein kinase 3D structures

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3D structures of serine/threonine protein kinase

Updated on 23-July-2024

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Michal Harel, Joel L. Sussman

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Serine/threonine protein kinase 3D structures

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3D structures of serine/threonine protein kinase

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@@ Line 14: / Line 14: @@
 **[[7akm]] - hChk1 kinase domain + ATP<br />
-**[[2cgu]], [[2cgv]], [[2cgw]], [[2cgx]], [[2c3j]], [[2c3k]], [[2c3l]], [[2br1]], [[2brb]], [[2brg]], [[2brh]], [[2brm]], [[2brn]], [[2bro]], [[2ayp]], [[2gdo]], [[2ghg]], [[2hog]], [[2ywp]], [[2hxl]], [[2hxq]], [[2hy0]], [[2r0u]], [[2e9n]], [[2e9o]], [[2e9p]], [[2e9u]], [[2e9v]], [[2qhm]], [[2qhn]], [[3f9n]], [[2wmq]], [[2wmr]], [[2wms]], [[2wmt]], [[2wmu]], [[2wmv]], [[2wmx]], [[3jvr]], [[3jvs]], [[2xey]], [[2xf0]], [[2xez]], [[2x8d]], [[2x8e]], [[2x8i]], [[3ot3]], [[3ot8]], [[3pa3]], [[3pa4]], [[3pa5]], [[3nlb]], [[2wmw]], [[2ydi]], [[2ydj]], [[2ydk]], [[2yer]], [[2yex]], [[2ym3]], [[2ym4]], [[2ym5]], [[2ym6]], [[2ym7]], [[2ym8]], [[3tkh]], [[3tki]], [[3u9n]], [[4fsm]], [[4fsn]], [[4fsq]], [[4fsr]], [[4fst]], [[4fsu]], [[4fsw]], [[4fsy]], [[4fsz]], [[4ft0]], [[4ft3]], [[4ft5]], [[4ft7]], [[4ft9]], [[4fta]], [[4ftc]], [[4fti]], [[4ftj]], [[4ftk]], [[4ftl]], [[4ftm]], [[4ftn]], [[4fto]], [[4ftq]], [[4ftr]], [[4ftt]], [[4ftu]], [[4gh2]], [[4hyh]], [[4hyi]], [[4jik]], [[4rvm]], [[4rvl]], [[4rvk]], [[4qyh]], [[4qyg]], [[4qyf]], [[4qye]], [[5dls]], [[5f4n]], [[6fc8]], [[5fcf]], [[5fck]], [[6fck]], [[6fcf]], [[7bko]] - hChk1 kinase domain + inhibitor<br />
+**[[2cgu]], [[2cgv]], [[2cgw]], [[2cgx]], [[2c3j]], [[2c3k]], [[2c3l]], [[2br1]], [[2brb]], [[2brg]], [[2brh]], [[2brm]], [[2brn]], [[2bro]], [[2ayp]], [[2gdo]], [[2ghg]], [[2hog]], [[2ywp]], [[2hxl]], [[2hxq]], [[2hy0]], [[2r0u]], [[2e9n]], [[2e9o]], [[2e9p]], [[2e9u]], [[2e9v]], [[2qhm]], [[2qhn]], [[3f9n]], [[2wmq]], [[2wmr]], [[2wms]], [[2wmt]], [[2wmu]], [[2wmv]], [[2wmx]], [[3jvr]], [[3jvs]], [[2xey]], [[2xf0]], [[2xez]], [[2x8d]], [[2x8e]], [[2x8i]], [[3ot3]], [[3ot8]], [[3pa3]], [[3pa4]], [[3pa5]], [[3nlb]], [[2wmw]], [[2ydi]], [[2ydj]], [[2ydk]], [[2yer]], [[2yex]], [[2ym3]], [[2ym4]], [[2ym5]], [[2ym6]], [[2ym7]], [[2ym8]], [[3tkh]], [[3tki]], [[3u9n]], [[4fsm]], [[4fsn]], [[4fsq]], [[4fsr]], [[4fst]], [[4fsu]], [[4fsw]], [[4fsy]], [[4fsz]], [[4ft0]], [[4ft3]], [[4ft5]], [[4ft7]], [[4ft9]], [[4fta]], [[4ftc]], [[4fti]], [[4ftj]], [[4ftk]], [[4ftl]], [[4ftm]], [[4ftn]], [[4fto]], [[4ftq]], [[4ftr]], [[4ftt]], [[4ftu]], [[4gh2]], [[4hyh]], [[4hyi]], [[4jik]], [[4rvm]], [[4rvl]], [[4rvk]], [[4qyh]], [[4qyg]], [[4qyf]], [[4qye]], [[5dls]], [[5f4n]], [[6fc8]], [[5fcf]], [[5fck]], [[6fck]], [[6fcf]], [[7bko]], [[8e80]]. ]]8o81]] - hChk1 kinase domain + inhibitor<br />
-**[[5oot]], [[5op2]], [[5op4]], [[5op5]], [[5op7]], [[5opb]], [[5opr]], [[5ops]], [[5opu]], [[5opv]], [[5oq5]], [[5oq6]], [[5oq7]], [[5oq8]], [[7bjd]], [[7bjh]], [[7bjj]], [[7bjm]], [[7bjo]], [[7bjr]], [[7bjx]], [[7bk1]], [[7bk2]], [[7bk3]], [[7mck]], [[7suf]], [[7sug]], [[7sujh], [[7sui]], [[7suj]]   - hChk1 kinase domain (mutant) + inhibitor<br />
+**[[5oot]], [[5op2]], [[5op4]], [[5op5]], [[5op7]], [[5opb]], [[5opr]], [[5ops]], [[5opu]], [[5opv]], [[5oq5]], [[5oq6]], [[5oq7]], [[5oq8]], [[7bjd]], [[7bjh]], [[7bjj]], [[7bjm]], [[7bjo]], [[7bjr]], [[7bjx]], [[7bk1]], [[7bk2]], [[7bk3]], [[7mck]], [[7suf]], [[7sug]], [[7suh]], [[7sui]], [[7suj]], [[8siv]], [[8siw]], [[8six]]  - hChk1 kinase domain (mutant) + inhibitor<br />
 **[[5oop]] - hChk1 kinase domain (mutant) + AMPPNP<br />
 **[[5oor]] - hChk1 kinase domain (mutant) + staurosporine<br />
@@ Line 40: / Line 40: @@
 **[[4lgd]] – hChk3 kinase domain + RASSF5 SARAH domain<br />
 **[[6ao5]] – hChk3 kinase+SARAH domains (mutant) + SAV1 SARAH domain<br />
-**[[5dh3]] – hChk3 kinase domain + inhibitor<br />
+**[[5dh3]], [[8a66]] – hChk3 kinase domain + inhibitor<br />
 *'''Chk4 (Mst1)''' ); Domains – kinase 1-311; SARAH 432-480
 **[[3com]] – hChk4 kinase domain<br />
-**[[6yat]] – hChk4 kinase domain + inhibitor<br />
+**[[6yat]], [[8a5j]] – hChk4 kinase domain + inhibitor<br />
 **[[4nr2]] – hChk4 SARAH domain<br />
 **[[2jo8]] – hChk4 SARAH domain - NMR<br />
@@ Line 67: / Line 67: @@
 **[[6cpf]] – hChk6 kinase domain + AMPPCP<br />
 **[[5g15]] – hChk6 kinase domain + AMPPNP + monobody<br />
-**[[6cpg]] – hChk6 kinase domain + inhibitor + monobody<br />
+**[[6cpg]], [[8ssp]] – hChk6 kinase domain + inhibitor + monobody<br />
-**[[2j4z]], [[2j50]], [[2np8]], [[3efw]], [[2x81]], [[2x6d]], [[2x6e]], [[3myg]], [[3vap]], [[4b0g]], [[4j8m]], [[5dpv]], [[5dr6]], [[5dr9]], [[5dt0]], [[5ew9]], [[5one]], [[5obr]], [[4byi]], [[4byj]], [[4jai]], [[4jaj]], [[3w10]], [[3w16]], [[3w18]], [[3w2c]], [[4uzh]], [[4uzd]], [[4uyn]], [[4zs0]], [[4ztq]], [[4ztr]], [[4zts]], [[5aad]], [[5aae]], [[5aag]], [[5dr6]], [[5dr9]], [[5dt0]], [[5ew9]], [[5obr]], [[5one]], [[6gra]], [[6c2t]], [[6c2r]], [[5zan]], [[6z4y]] – hChk6 kinase domain + inhibitor<br />
+**[[2j4z]], [[2j50]], [[2np8]], [[3efw]], [[2x81]], [[2x6d]], [[2x6e]], [[3myg]], [[3vap]], [[4b0g]], [[4j8m]], [[5dpv]], [[5dr6]], [[5dr9]], [[5dt0]], [[5ew9]], [[5one]], [[5obr]], [[4byi]], [[4byj]], [[4jai]], [[4jaj]], [[3w10]], [[3w16]], [[3w18]], [[3w2c]], [[4uzh]], [[4uzd]], [[4uyn]], [[4zs0]], [[4ztq]], [[4ztr]], [[4zts]], [[5aad]], [[5aae]], [[5aag]], [[5dr6]], [[5dr9]], [[5dt0]], [[5ew9]], [[5obr]], [[5one]], [[6gra]], [[6c2t]], [[6c2r]], [[5zan]], [[6z4y]], [[7ayh]], [[7ayi]], [[7fic]], [[7o2v]], [[8jmx]] – hChk6 kinase domain + inhibitor<br />
 **[[2bmc]], [[2c6e]], [[3coh]], [[3h0y]], [[3h0z]], [[3h10]], [[3fdn]], [[2wtw]], [[3lau]], [[3nrm]], [[2xne]], [[2xng]], [[2xru]], [[3k5u]], [[3m11]], [[3p9j]], [[3r21]], [[3r22]], [[3qbn]], [[3unz]], [[3uo4]], [[3uo5]], [[3uo6]], [[3uod]], [[3uoh]], [[3uoj]], [[3uok]], [[3uol]], [[3up2]], [[3up7]], [[4dhf]], [[4dea]], [[4deb]], [[4ded]], [[4dee]], [[5aad]], [[5aae]], [[5aaf]], [[5aag]], [[4jbo]], [[4jbp]], [[4jbq]], [[4prj]], [[5dpv]], [[6hjk]], [[6hjj]] – hChk6 kinase domain (mutant) + inhibitor<br />
 **[[5dt4]], [[5obj]] – hChk6 kinase domain + ATP + inhibitor<br />
@@ Line 74: / Line 74: @@
 **[[5dn3]], [[5dos]], [[5dt4]], [[5obj]] – hChk6 kinase domain + ATP + inhibitor <br />
 **[[6c83]] – hChk6 kinase domain + AMPPCP + nanobody<br />
+**[[8sso]] – hChk6 kinase domain + drug + monobody<br />
 **[[5dr2]] – hChk6 kinase domain (mutant) + ATP + inhibitor <br />
-**[[5g1x]] – hChk6 kinase domain (mutant) + N-Myc <br />
+**[[5g1x]], [[7ztl]] – hChk6 kinase domain (mutant) + N-Myc <br />
+**[[8guw]] – hChk6 kinase domain/activator peptide <br />
 **[[5l8j]], [[5l8k]], [[5l8l]] – hChk6 kinase domain (mutant) + new antigen receptor variable domain <br />
 **[[5lxm]] – hChk6 kinase domain (mutant) + Targeting protein for XKLP2 <br />
@@ Line 112: / Line 114: @@
 *'''Chk13 (Polo-like kinase Plk)'''
-*Plk1 Polo-box domain (Pbd)''
+*Plk1 Polo-box domain (Pbd) 371-594''
 **[[1q4o]], [[2ogq]], [[3hih]], [[3p2w]], [[4h5x]], [[6n46]] – hPlk1 Pbd<br />
+**[[8joq]], [[8joy]] – hPlk1 Pbd + hpv peptide<br />
 *Plk1 Pbd complex with polypeptide
-**[[1umw]], [[2ojx]], [[3bzi]], [[3c5l]], [[3rq7]], [[4dfw]], [[4whl]], [[4whk]], [[4whh]], [[4rcp]], [[4o6w]], [[4o56]], [[5dms]], [[5dmv]], [[5dnj]]  – hPlk1 + peptide<br />
+**[[1umw]], [[2ojx]], [[3bzi]], [[3c5l]], [[3rq7]], [[4dfw]], [[4whl]], [[4whk]], [[4whh]], [[4rcp]], [[4o6w]], [[4o56]], [[5dms]], [[5dmv]], [[5dnj]], [[7mso]], [[7mx1]]  – hPlk1 + peptide<br />
 **[[3hik]], [[3fvh]], [[3p2z]], [[3p34]], [[3p35]], [[3p36]], [[3p37]], [[3q1i]], [[4e67]], [[4e9c]], [[4e9d]], [[4hab]], [[4hy2]], [[4o9w]],  [[4x9r]], [[4x9v]], [[4x9w]], [[5j19]], [[6gy2]] – hPlk1 + phosphopeptide<br />
 **[[1q4k]] – hPlk1 (mutant) + phosphopeptide<br />
@@ Line 126: / Line 129: @@
 **[[6ax4]] – hChk Plk1 + histidine cyclized macrocycle <br />
 **[[5x3s]] – mPlk1 + phosphopeptide<br />
+**[[8joq]], [[8joy]] – hPlk1 Pbd + hpv peptide<br />
 *Plk1 Pbd complex with small molecule inhibitor
-**[[4h71]], [[4hco]], [[5ta6]], [[5ta8]] – hPlk1 + inhibitor<br />
+**[[4h71]], [[4hco]], [[5ta6]], [[5ta8]], [[8bjt]], [[8crc]] – hPlk1 + inhibitor<br />
 **[[2rku]] – hPlk1 (mutant) + inhibitor<br />
 **[[3db6]], [[3db8]], [[3dbc]], [[3dbd]], [[3dbe]], [[3dbf]] – zfPlk1 (mutant) + inhibitor – zebra fish<br />
-*Plk1 catalytic domain
+*Plk1 catalytic domain 36-345
 **[[2owb]] – hPlk1 catalytic domain (mutant)<br />
@@ Line 162: / Line 166: @@
 **[[5lhy]] – hChk Plk4 Pb3 domain<br />
 **[[4yyp]], [[5lhz]] – hChk Plk4 Pb3 domain + Scl-interrupting locus protein <br />
-**[[4nk7]], [[4g7n]], [[5lhx]] – DmChk Plk4 Pbd domain – ''Drosophila melanogaster''<br />
+**[[4nk7]], [[4g7n]], [[5lhx]], [[7rl3]] – DmChk Plk4 Pbd domain – ''Drosophila melanogaster''<br />
 *'''Chk16'''
@@ Line 171: / Line 175: @@
 **[[3lm0]] – hChk17B  <br />
-**[[6qf4]] – hChk17B  + ADP<br />
+**[[6qf4]], [[7q7c]], [[7q7d]] – hChk17B  + ADP<br />
+**[[7q7e]] – hChk17B  + ATP<br />
 **[[3lm5]] – hChk17B  + quercetin<br />
 **[[6y6f]], [[6y6h]], [[6zjf]] – hChk17B  + pyrimidine derivative<br />
 **[[7akg]] – hChk17B + drug<br />
-*'''Chk24 (Mst3)'''
+*'''Chk19''' or STK19
+**[[7xrb]] – hChk19  <br />
+*'''Chk24 (Mst3)''' or STK24
 **[[3a7f]], [[3a7g]], [[3a7h]], [[3a7i]], [[3a7j]], [[3ckw]] – hChk24 kinase domain <br />
-**[[4w8e]], [[4w8d]], [[4u8z]], [[4qmm]], [[4qmn]], [[4qmo]], [[4qmp]], [[4qmq]], [[4qms]], [[4qmt]], [[4qmu]], [[4qmv]], [[4qmw]], [[4qmx]], [[4qmy]], [[4qmz]], [[4qna]], [[4qo9]], [[4u8z]], [[7b30]], [[7b31]], [[7b32]], [[7b33]], [[7b34]], [[7b35]] – hChk Mst3 + inhibitor <br />
+**[[4w8e]], [[4w8d]], [[4u8z]], [[4qmm]], [[4qmn]], [[4qmo]], [[4qmp]], [[4qmq]], [[4qms]], [[4qmt]], [[4qmu]], [[4qmv]], [[4qmw]], [[4qmx]], [[4qmy]], [[4qmz]], [[4qna]], [[4qo9]], [[4u8z]], [[7b30]], [[7b31]], [[7b32]], [[7b33]], [[7b34]], [[7b35]], [[8bzi]], [[8bzj]], [[8qlr]], [[8qls]], [[8qlt]] – hChk Mst3 + inhibitor <br />
+**[[8qlq]] – hChk Mst3 + macrocyclic inhibitor <br /> or STK2
 **[[3ckx]] – hChk24 kinase domain + staurosporin <br />
 **[[3zhp]] – hChk24 kinase domain + calcium-binding protein <br />
@@ Line 185: / Line 195: @@
 **[[4qml]] – hChk Mst3 kinase domain + AMPPNP <br />
-*'''Chk25'''
+*'''Chk25 or STK25'''
 **[[2xik]] – hChk25 kinase domain<br />
+**[[7z4v]] – hChk25 kinase domain + inhibitor<br />
 **[[3w8h]] – hChk25 regulatory domain + programmed cell death protein 10<br />
 **[[4nzw]] – hChk25 kinase domain (mutant) + calcium-binding protein <br />
@@ Line 227: / Line 238: @@
 **[[1unp]], [[1unr]] – hRac-α hChk pleckstrin homology domain <br />
-**[[2uzr]], [[2uzs]] – hRac-α hChk pleckstrin homology domain (mutant) <br />
+**[[2uzr]], [[2uzs]], [[7myx]] – hRac-α hChk pleckstrin homology domain (mutant) <br />
 **[[1h10]], [[1unq]], [[2uvm]] – hRac-α hChk pleckstrin homology domain + inositol tetrakisphosphate<br />
 **[[3o96]], [[4ejn]], [[6s9w]], [[6s9x]], [[6hhj]], [[6hhi]], [[6hhh]], [[6hhg]], [[6hhf]] - hRac-α hChk + inhibitor<br />
@@ Line 239: / Line 250: @@
 **[[7apj]] - hRac-α hChk + nanobody<br />
-*'''Rac-β hChk'''
+*'''Rac-β hChk or AKT2'''
 **[[1gzk]], [[1gzn]], [[1gzo]], [[1mrv]], [[1mry]] – hRac-β hChk kinase domain<br />
@@ Line 247: / Line 258: @@
 **[[3e87]], [[3e88]], [[3e8d]] - Rac-β hChk kinase domain (mutant) + GSK3 peptide + inhibitor<br /
 **[[1o6l]] - hRac-β hChk kinase domain (mutant) + GSK3 peptide + AMPPNP<br />
-**[[3d0e]] - hRac-β hChk kinase domain (mutant) + inhibitor<br />
+**[[3d0e]], [[8q61]] - hRac-β hChk kinase domain (mutant) + inhibitor<br />
-*'''Rac-γ hChk (ATK3)'''
+*'''Rac-γ hChk (AKT3)'''
 **[[2x18]] – Rac-γ hChk PH domain<br />
@@ Line 260: / Line 271: @@
 *'''B-Raf'''; domains - BRS 38-116; Ras-binding 153-237; kinase 445-723
-**[[1uwh]], [[3c4c]], [[6v2u]], [[6xfp]], [[6xlo]] – hB-Raf kinase domain + anticancer drug<br />
+**[[8dgs]], [[8dgt]] – hB-Raf in Ras/Raf complex – Cryo EM<br />
+**[[7zr5]] – hB-Raf + Hsp90 + CDC37 + PP5 – Cryo EM<br />
+**[[1uwh]], [[3c4c]], [[6v2u]], [[6xfp]], [[6xlo]], [[8f7o]], [[8f7p]] – hB-Raf kinase domain + anticancer drug<br />
 **[[1uwj]], [[6p3d]] – hB-Raf kinase domain (mutant) + anticancer drug<br />
-**[[2fb8]], [[3d4q]], [[3ii5]], [[3psd]], [[3skc]], [[3tv6]], [[4g9c]], [[4ksp]], [[4ksq]], [[3psb]], [[3ppj]], [[3ppk]], [[3prf]], [[3pri]], [[3tv4]], [[4dbn]], [[4e4x]], [[4mbj]], [[4ehe]], [[3q4c]], [[3q96]], [[3e26]], [[4h58]], [[4e26]], [[4fc0]], [[4pp7]], [[6cad]] – hB-Raf kinase domain + pyrazole inhibitor<br />
+**[[2fb8]], [[3d4q]], [[3ii5]], [[3psd]], [[3skc]], [[3tv6]], [[4g9c]], [[4ksp]], [[4ksq]], [[3psb]], [[3ppj]], [[3ppk]], [[3prf]], [[3pri]], [[3tv4]], [[4dbn]], [[4e4x]], [[4mbj]], [[4ehe]], [[3q4c]], [[3q96]], [[3e26]], [[4h58]], [[4e26]], [[4fc0]], [[4pp7]], [[6cad]], [[7shv]] – hB-Raf kinase domain + pyrazole inhibitor<br />
 **[[4jvg]], [[4ehg]], [[4fk3]], [[3idp]], [[4g9r]], [[4wo5]], [[4mnf]], [[4r5y]], [[4rzv]], [[4rzw]], [[4xv1]], [[4xv2]], [[4xv3]], [[4xv9]], [[4yht]], [[5c9c]], [[5hi2]], [[5ita]], [[5jrq]], [[5jsm]], [[5jt2]], [[6nsq]], [[6p7d]], [[6uuo]] – hB-Raf kinase domain (mutant) + pyrazole inhibitor<br />
-**[[5csw]], [[5csx]], [[5ct7]], [[5fd2]], [[5hid]], [[5hie]], [[5val]], [[5vam]], [[6b8u]], [[6n0q]], [[6n0p]], [[7k0v]], [[7p3b]], [[7p3v]] - hB-Raf kinase domain + inhibitor<br />
+**[[5csw]], [[5csx]], [[5ct7]], [[5fd2]], [[5hid]], [[5hie]], [[5val]], [[5vam]], [[6b8u]], [[6n0q]], [[6n0p]], [[7k0v]], [[7p3b]], [[7p3v]], [[8c7x]], [[8c7y]] - hB-Raf kinase domain + inhibitor<br />
 **[[6v34]] – hB-Raf kinase domain (mutant) + inhibitor<br />
 **[[4mne]] – hB-Raf kinase domain + MAPKK1<br />
+**[[8f7o]] – hB-Raf kinase domain + drug<br />
+**[[7m0u]] – hB-Raf kinase domain + AMPPNP + drug<br />
 **[[6u2h]] – hB-Raf kinase domain + 14-3-3 ζ/δ<br />
 **[[7mfe]] – hB-Raf + 14-3-3 ζ/δ – Cryo EM<br />
@@ Line 272: / Line 287: @@
 **[[7mfd]] – hB-Raf + 14-3-3 ζ/δ + MEK + inhibitor – Cryo EM<br />
 **[[6pp9]] – hB-Raf kinase domain + MEK1 + ANP<br />
+**[[7m0x]], [[7m0z]] – hB-Raf kinase domain + MEK1 + ANP + inhibitor<br />
+**[[7m0t]], [[7m0u]], [[7m0v]], [[7m0w]], [[7m0y]] – hB-Raf kinase domain + MEK1 + ANP + drug<br />
 **[[6u2g]] – hB-Raf kinase domain + MEK1 + AMPPCP<br />
 **[[5vr3]] – hB-Raf BRS domain <br />
@@ Line 299: / Line 316: @@
 **[[4g0n]], [[4g3x]] – hc-Raf RAS-binding domain + GTPase Hras <br />
 **[[3kud]] – hc-Raf RAS-binding domain (mutant) + GTPase Hras <br />
+**[[8epw]] – hc-Raf RAS-binding domain + GTPase Kras <br />
+**[[8atr]], [[8ats]], [[8avo]] – hc-Raf RAS-binding domain + 14-3-3 protein sigma <br />
 **[[6xgu]], [[6xgv]], [[6xha]], [[6xhb]] – hc-Raf RBD+CRD domains 52-188 + GTPase Kras + GMPPNP<br />
+**[[7z5r]], [[8gae]] – hc-Raf RBD domain + Hsp84 + Cdc37 + PP5 + ADP + ATP – Cryo EM<br />
+**[[7zr0]] – hc-Raf RBD domain + Hsp84 + Cdc37 + ATP – Cryo EM<br />
 *'''Snf1-related Chk'''
@@ Line 316: / Line 337: @@
 **[[6cj5]], [[6cje]], [[6cjh]], [[6cjw]], [[6cjy]], [[6ck3]], [[6ck6]], [[6cki]] – hMnk 2 catalytic domain (mutant) + inhibitor<br />
-*'''hChk Pak''' or '''Chk N''' or '''PRK1''';Domains - CRIB 74-109; Hr1B 122-199; kinase 605-942
+*'''hChk Pak''' or '''Chk N''' or '''PRK1''';Domains - CRIB 74-109; Hr1B 122-199; catalytic 109-426; kinase 605-942
 **[[1urf]] – hChk Pak-1 Hr1b domain - NMR<br />
@@ Line 324: / Line 345: @@
 **[[4otd]] - hChk Pak-1 kinase domain<br />
 **[[1yhv]], [[1yhw]], [[3q4z]], [[3q52]], [[3q53]] – hChk Pak-1 kinase domain (mutant)<br />
-**[[4o0r]], [[4o0t]], [[4zji]], [[4zjj]], [[4zlo]], [[4zy4]], [[4zy5]], [[4zy7]], [[5ime]], [[5kbq]], [[5kbr]], [[6b16]]  – hChk Pak-1 kinase domain + inhibitor<br />
+**[[4o0r]], [[4o0t]], [[4zji]], [[4zjj]], [[4zlo]], [[4zy4]], [[4zy5]], [[4zy7]], [[5ime]], [[5kbq]], [[5kbr]], [[6b16]], [[7vto]]  – hChk Pak-1 kinase domain + inhibitor<br />
 **[[4oti]], [[4oth]], [[4otg]] – hChk Pak-1 kinase domain + inhibitor<br />
 **[[4eqc]], [[4p90]], [[5dew]], [[5dey]], [[5dfp]] – hChk Pak-1 kinase domain (mutant) + inhibitor<br />
@@ Line 340: / Line 361: @@
 **[[5upl]], [[5upk]] – hChk Pak-4 kinase domain (mutant) + CDC42<br />
 **[[5ved]] – hChk Pak-4 kinase domain + staurosporine<br />
+**[[8ahi]] – hChk Pak-4 300-591 + inhibitor<br />
+**[[7s46]], [[7s48]] – hChk Pak-4 catalytic domain + integrin beta-5 peptide<br />
 **[[2c30]] – hChk Pak-6<br />
 **[[2odb]] – hChk Pak-6 CRIB domain + CDC42<br />
@@ Line 367: / Line 390: @@
 **[[4y12]] - MtChk PknG + ATP-gS<br />
 **[[4y0x]] - MtChk PknG + ADP<br />
+**[[7q52]] - MtChk PknG + inhibitor<br />
 **[[4esq]] - MtChk PknH extracellular domain<br />
 **[[5m06]], [[5xka]] - MtChk  PknI kinase domain <br />
@@ Line 378: / Line 402: @@
 **[[4b9d]] - hChk Nek1 kinase domain (mutant) + inhibitor<br />
 **[[2w5h]] – hChk Nek2 kinase domain<br />
-**[[2jav]], [[2wqo]], [[2xk3]], [[2xk4]], [[2xk6]], [[2xk7]], [[2xk8]], [[2xkc]], [[2xkd]], [[2xke]], [[2xkf]], [[2xnm]], [[2xnn]], [[2xno]], [[2xnp]], [[4a4x]], [[4afe]], [[5m51]], [[5m53]], [[5m55]], [[5m57]], [[6sk9]], [[6sgh]], [[6sgi]], [[6sgk]]  – hChk Nek2 + inhibitor<br />
+**[[2jav]], [[2wqo]], [[2xk3]], [[2xk4]], [[2xk6]], [[2xk7]], [[2xk8]], [[2xkc]], [[2xkd]], [[2xke]], [[2xkf]], [[2xnm]], [[2xnn]], [[2xno]], [[2xnp]], [[4a4x]], [[4afe]], [[5m51]], [[5m53]], [[5m55]], [[5m57]], [[6sgd]], [[6sk9]], [[6sgh]], [[6sgi]], [[6sgk]], [[8sk9]]  – hChk Nek2 + inhibitor<br />
 **[[2w5a]], [[2w5b]] – hChk Nek2 + nucleotide<br />
 **[[6tm5]] - hChk Nek2 in anaphase-promoting complex – Cryo EM<br />
@@ Line 392: / Line 416: @@
 **[[6fdo]], [[6fdn]], [[6fdm]] – hChk Rio2 <br />
 **[[4otp]] – hChk Rio1 Rio domain + ADP <br />
-**[[6hk6]] – hChk Rio2 + inhibitor <br />
+**[[6hk6]], [[7vbt]] – hChk Rio2 + inhibitor <br />
 **[[6eml]], [[6fai]], [[6g18]], [[6g51]], [[6rbd]],[[6rbe]],  [[6y7c]] – yChk Rio2 in 40S particle – Cryo EM<br />
 **[[1ztf]] – AfChk Rio1 + adenine derivative – ''Archaeoglobus fulgidus''<br />
@@ Line 409: / Line 433: @@
 **[[5uvf]], [[6cnx]], [[6bu6]], [[6cfm]], [[6dd4]], [[6bp0]], [[6bru]], [[6btw]], [[6cmm]], [[6cqh]], [[6csw]], [[6npn]], [[6vxu]], [[6vzh]] – hChk Vrk1 kinase domain (mutant) + inhibitor<br />
 **[[6ac9]] – hChk Vrk1 kinase domain (mutant) + AMPPNP<br />
+**[[7tan]] – hChk Vrk1 kinase domain + nucleosome – Cryo EM<br />
 **[[2v62]] – hChk Vrk2 kinase domain <br />
-**[[5uu1]], [[6ncg]] – hChk Vrk2 kinase domain + inhibitor<br />
+**[[5uu1]], [[6ncg]], [[8q1z]] – hChk Vrk2 kinase domain + inhibitor<br />
 *Chk Wnk (protein kinase lysine-deficient); Domains - kinase 194-483; CCT1 454-549
@@ Line 424: / Line 449: @@
 **[[5o26]], [[5tf9]] - hChk Wnk3 kinase domain + AMPPNP<br />
 **[[5o2b]] - hChk Wnk3 kinase domain + inhibitor<br />
+**[[8edh]] - hChk Wnk3 kinase domain (mutant) + inhibitor<br />
 **[[2lru]] – rChk Wnk1 autoinhibitory domain 480-572 - NMR<br />
 **[[5w7t]] - rChk Wnk1 kinase domain <br />
+**[[7uos]] - rChk Wnk1 kinase domain (mutant)<br />
 *'''TANK-binding kinase'''
@@ Line 496: / Line 523: @@
 **[[1aue]] – hFRAP FRB domain<BR />
 **[[2gaq]], [[2npu]] – hFRAP FRB domain - NMR<BR />
+**[[8ppz]] – hFRAP FRB domain + FKBP + pyridine derivative<BR />
 **[[3fap]], [[2fap]], [[4fap]] – hFRAP FRB domain + FKBP + rapamycin analog<BR />
 **[[4drh]], [[4dri]], [[4drj]], [[5gpg]] – hFRAP FRB domain + FKBP + rapamycin<BR />
@@ Line 518: / Line 546: @@
 **[[6sb0]] – hChk Mtor + RAPTOR + LST8 + RAGA + RAGC + proline-rich Akt1 substrate – Cryo EM <br />
 **[[5zcs]] – hmTOR + LST8 + AVO3 + TORC2 – Cryo EM <br />
-**[[6zwm]], [[6zwo]], [[7owg]], [[7pe7]], [[7pe8]], [[7pe9]], [[7pea]], [[7peb]], [[7pec]] – mTOR in mTor complex – Cryo EM <br />
+**[[7tzo]] – hTORC2 in mTORC2 complex– Cryo EM <br />
+**[[6zwm]], [[6zwo]], [[7owg]], [[7pe7]], [[7pe8]], [[7pe9]], [[7pea]], [[7peb]], [[7pec]], [[7uxc]], [[8era]] – mTOR in mTor complex – Cryo EM <br />
 *'''Gcn2'''
@@ Line 528: / Line 557: @@
 **[[1zyd]] – yChk Gcn2 + ATP<br />
 **[[4otn]] – mChk Gcn2 C terminal domain <br />
+*'''LRRK1''' or leucine-rich repeat Chk1
+**[[8e04]], [[8e05]], [[8e06]], [[8fac]] – hLRRK1 – Cryo EM <br />
 *'''LRRK2''' or leucine-rich repeat Chk2 or dardarin
@@ Line 534: / Line 567: @@
 **[[7lht]], [[7lhw]], [[7li4]] – hLRRK2 + ATP + GDP – Cryo EM <br />
 **[[7li3]] – hLRRK2 (mutant) + ATP + GDP – Cryo EM <br />
-**[[6oje]] – hLRRK2 GTPase domain 1329-1520<br />
+**[[6oje]], [[7thy]] – hLRRK2 GTPase domain 1329-1520<br />
 **[[6ojf]] – hLRRK2 GTPase domain (mutant) <br />
 **[[6dlo]], [[6dlp]] – hLRRK2 WD40 domain<br />
+**[[7thz]] – hLRRK2 1330-1527 + GDP <br />
 **[[6vno]], [[6vp6]], [[6vp7]] – hLRRK2 C terminal 1330-2527 – Cryo EM <br />
 **[[6vp8]] – hLRRK2 C terminal 1330-2527 + COR domain 1670-1950 + WD40 domain 2140-2489 – Cryo EM <br />
@@ Line 543: / Line 577: @@
 *'''Pim'''
-*Pim1; Domains catalytic 14-313; kinase 92-404
+*Pim1 catalytic domain residues 14-313
 **[[1xqz]], [[1ywv]], [[4jx3]] – hPim1 catalytic domain <br />
 **[[1yxs]] – hPim1 catalytic domain (mutant) <br />
-**[[4jx3]] – hPim1 kinase domain <br />
 **[[1xr1]], [[1yxt]] – hPim1 catalytic domain + AMPPNP <br />
 **[[1yxu]] – hPim1 catalytic domain + AMP <br />
-**[[1yxv]] – hPim1 catalytic domain + quinoline derivative <br />
+**[[1yxv]], [[5ipj]] – hPim1 catalytic domain + quinoline derivative <br />
-**[[3uix]] – hPim1 kinase domain residues 120-404 + quinoline derivative <br />
 **[[1yxx]] – hPim1 catalytic domain + indole derivative <br />
-**[[3a99]] – hPim1 kinase domain + phosphoaminophosphonic acid adenylate <br />
 **[[2bzj]], [[2bzh]], [[2bzi]] – hPim1 catalytic domain  (mutant) + organometallic ligand <br />
+**[[2o3p]], [[2o63]], [[2o64]], [[2o65]], [[3c4e]], [[3jxw]], [[3jy0]], [[3jya]], [[3r00]], [[3r01]], [[3r02]], [[3r04]], [[3vbq]], [[3vbt]], [[3vbv]], [[3vbw]], [[3vbx]], [[3vby]], [[3vc4]], [[3umw]], [[3umx]], [[4enx]], [[4eny]], [[4k1b]], [[4k18]], [[4k0y]], [[4iaa]], [[4i41]], [[4ll5]], [[4lm5]], [[4lmu]], [[4mta]], [[6kzi]], [[4mbl]], [[4mbi]], [[4n6y]], [[4n6z]], [[4n70]], [[4xh6]], [[5iis]], [[5kgd]], [[5kge]], [[5kgg]], [[5kgi]], [[5kgk]], [[5kzi]], [[5vua]], [[5vub]], [[5vuc]], [[6mt0]], [[6vrv]], [[7oov]], [[7oow]], [[7oox]], [[7xsv]] – hPim1 catalytic domain + inhibitor <br />
+**[[2j2i]], [[3we8]] – hPim1 catalytic domain (mutant)+ inhibitor <br />
+*Pim1 kinase domain residues 92-404
+**[[4jx3]] – hPim1 kinase domain <br />
+**[[3uix]], [[5c1q]] – hPim1 kinase domain residues 120-404 + quinoline derivative <br />
+**[[3a99]] – hPim1 kinase domain + phosphoaminophosphonic acid adenylate <br />
 **[[2oi4]], [[3bwf]] – hPim1 kinase domain  (mutant) + organometallic ligand <br />
-**[[1xws]], [[4dtk]], [[4as0]], [[4alu]], [[4alv]], [[4alw]], [[4bzn]], [[4bzo]],  [[6bsk]], [[5v80]], [[5v82]]. [[5toe]], [[5tex]], [[5tel]], [[5o11]], [[5o12]], [[5o13]], [[6no8]], [[6no9]], [[6kzi]], [[6l11]], [[6l12]], [[6l13]], [[6l14]], [[6l15]], [[6l16]], [[6l17]], [[6vru]], [[6ykd]] – hPim1 kinase domain + inhibitor <br />
+**[[1xws]], [[4alu]], [[4alv]], [[4alw]], [[4as0]], [[4bzn]], [[4bzo]], [[4dtk]], [[4jx7]], [[4rbl]], [[4rc2]], [[4rc3]], [[4rc4]], [[4ty1]], [[4wrs]], [[4wsy]], [[4wt6]], [[4xhk]], [[[5dgz]], [5dhj]], [[5dia]], [[5dwr]], [[5eol]], [[5kcx]], [[5o11]], [[5o12]], [[5o13]], [[5tel]], [[5tex]], [[5toe]], [[5v80]], [[5v82]]. [[6bsk]], [[6l11]], [[6l12]], [[6l13]], [[6l14]], [[6l15]], [[6l16]], [[6l17]], [[6no8]], [[6no9]], [[6vru]], [[6ykd]], [[7zun]] – hPim1 kinase domain + inhibitor <br />
 **[[6ayd]] – hPim1 kinase domain (mutant)+ inhibitor <br />
-**[[2o3p]], [[2o63]], [[2o64]], [[2o65]], [[3jxw]], [[3jy0]], [[3jya]], [[3r00]], [[3r01]], [[3r02]], [[3r04]], [[3vbq]], [[3vbt]], [[3vbv]], [[3vbw]], [[3vbx]], [[3vby]], [[3vc4]], [[3umx]], [[4enx]], [[4eny]], [[3umw]], [[4ll5]], [[4lm5]], [[3c4e]], [[5vuc]], [[5vub]], [[5vua]], [[4n70]], [[4n6z]], [[4n6y]], [[4mta]], [[6kzi]], [[4mbl]], [[4mbi]], [[4lmu]], [[4k1b]], [[4k18]], [[4k0y]], [[4iaa]], [[4i41]], [[6mt0]], [[7oov]], [[7oow]], [[7oox]]  – hPim1 catalytic domain + inhibitor <br />
-**[[2j2i]], [[3we8]] – hPim1 catalytic domain (mutant)+ inhibitor <br />
-**[[5tur]] - hPim1 + inhibitor <br />
-*Pim1 complex with consensus peptide
+*Pim1 full length
+**[[4rpv]], [[5tur]] - hPim1 + inhibitor <br />
+*Pim1 complex with consensus peptide (pimtide)
 **[[2bil]], [[3cxw]], [[3cy2]], [[3cy3]], [[6qxk]], [[6pcw]], [[6pdi]], [[6pdn]], [[6pdo]], [[6pdp]] – hPim1 kinase domain + inhibitor + consensus peptide<br />
 **[[3jpv]], [[3qf9]] - hPim1 catalytic domain + inhibitor + consensus peptide<br />
 **[[2c3i]], [[5ndt]], [[5n5m]], [[5n5l]], [[5n52]], [[5n51]], [[5n50]], [[5n4z]], [[5n4y]], [[5n4x]], [[5n4v]], [[5n4u]], [[5n4r]], [[5n4o]], [[5n4n]], [[5mzl]] – hPim1 kinase domain (mutant) + inhibitor + consensus peptide <br />
-**[[4gw8]] – hPim1 catalytic domain (mutant) + inhibitor + consensus peptide <br />
+**[[4gw8]], [[7qb2]], [[7qfm]], [[7z6u]], [[8afr]] – hPim1 catalytic domain (mutant) + inhibitor + pimtide<br />
 **[[2bzk]] – hPim1 kinase domain (mutant)+ AMPPNP + consensus peptide <br />
 **[[3ma3]] – hPim1 catalytic domain + inhibitor + PSer + consensus peptide<br />
@@ Line 586: / Line 626: @@
 **[[6ac5]] – hRip1 death domain <br />
-**[[6r5f]], [[6nw2]], [[6c4d]], [[6c3e]], [[5tx5]], [[7fcz]], [[7fd0]] – hRip1 catalytic domain + inhibitor  <br />
+**[[6r5f]], [[6nw2]], [[6c4d]], [[6c3e]], [[5tx5]], [[7fcz]], [[7fd0]], [[7ydx]] – hRip1 catalytic domain + inhibitor  <br />
 **[[6rln]], [[6ocq]], [[6nyh]], [[6hho]] – hRip1 catalytic domain (mutant) + inhibitor  <br />
 **[[6ggs]] – hRip2 – Cryo EM  <br />
@@ Line 592: / Line 632: @@
 **[[6szj]], [[6sze]], [[6s1f]], [[6rna]], [[6rn8]], [[6hmx]], [[6fu5]], [[6es0]], [[5w5o]], [[5w5j]] – hRip2 catalytic domain + inhibitor  <br />
 **[[6ul8]] – hRip2 catalytic domain (mutant) + inhibitor  <br />
+**[[8aza]] – hRip2 catalytic domain + XiaP Bir2 domain – Cryo EM <br />
 **[[7mx3]] – hRip3 catalytic domain (mutant) + inhibitor  <br />
 **[[7mon]] – hRip3 catalytic domain (mutant) + MLKL <br />
@@ Line 609: / Line 650: @@
 **[[5ci7]], [[6mnh]] – hChk Ulk1 (mutant) + inhibitor<br />
 **[[4wnp]], [[4wno]] – hChk Ulk1 + IST1 homolog<br />
+**[[8soi]], [[8sqz]] – hChk Ulk1 + RB1-inducible coiled-coil protein + autophagy-related protein<br />
+**[[8srm]] – hChk Ulk1 + RB1-inducible coiled-coil protein + autophagy-related protein – Cryo EM<br />
+**[[9c82]] – hChk Ulk1 + RB1-inducible coiled-coil protein + autophagy-related protein + PI3K – Cryo EM<br />
 **[[6qav]], [[6qau]], [[6qat]], [[6yid]] – hChk Ulk2 + inhibitor<br />
 **[[4wzx]] – hChk Ulk3 MIT 2 domain + inhibitor<br />
@@ Line 631: / Line 675: @@
 *'''Chk Smg'''
 **[[6l53]] – hChk Smg1 – Cryo EM  <br />
@@ Line 645: / Line 688: @@
 **[[4um2]] – hChk Smg6 TPR domain <br />
 **[[1ya0]] – hChk Smg7 N terminal <br />
+*'''Chk Vprbp or DCAF1'''
+**[[4pxw]], [[8ood]] – hChk Vprbp WD repeat domain 1039-1401 (mutant) <br />
+**[[7sse]], [[7ufv]], [[8f8e]], [[8og5]], [[8og6]], [[8og7]], [[8og8]], [[8og9]], [[8oga]], [[8ogb]], [[8ogc]], [[8oo5]], [[8ood]] – hChk Vprbp WD repeat domain (mutant) + inhibitor<br />
+**[[5aja]] – hChk Vprbp WD repeat domain  + VPX + SAMHD1<br />
 *'''Other Chk'''
@@ Line 652: / Line 701: @@
 **[[7okw]] – hChk Osr1 C-terminal  <br />
 **[[4aw2]] – hChk Mrckα kinase domain<br />
-**[[4pxw]] – hChk Vprbp WD repeat domain (mutant)<br />
+**[[4pxw]], [[8ood]] – hChk Vprbp WD repeat domain (mutant)<br />
+**[[7v7c]] – hChk Vprbp in DDB1-VPRBP-VPR-UNG2 complex – Cryo EM<br />
+**[[7v7c]] – hChk Vprbp in DDB1-VPRBP-VPR-UNG2 complex – Cryo EM<br />
 **[[1uf0]] – hChk Dcamkl1 DCX domain – NMR<br />
 **[[1u5q]] – rChk Tao2 kinase domain <br />
@@ Line 675: / Line 726: @@
 **[[6sl1]], [[6sl0]], [[6skz]], [[6sky]] – Chk Tel1 – ''Chaetonium thermophilum'' – Cryo EM<br />
 **[[6ra0]] – CeChk Dkf1 – ''Chaenorhabditis elegans''<br /><br />
+**[[7z6e]] – CeChk Mrck1 regulatory domain<br />
 **[[6tlb]] – Chk – ''Plasmodium falciparum''<br />
 *Other Chk complexes
-**[[1wbp]] – hChk Sprk1 + peptide<br />
+**[[1wbp]], [[7dd1]] – hChk Sprk1 + peptide<br />
 **[[3beg]] – hChk Srpk1 + splicing factor SF2<br />
 **[[3hdm]], [[3hdn]], [[7pue]] – hChk Sgk1 (mutant) + inhibitor <br />
@@ Line 719: / Line 771: @@
 **[[6s8f]] – yChk Tel1 + AMPPNP – Cryo EM<br />
 **[[5yyz]] – yChk Mek1 FHA domain + Hop1<br />
-**[[5x6o]], [[6z3a]] – yChk Mec1 + LCD1 – Cryo EM<br />
+**[[5x6o]], [[6z3a]], [[7wzr]], [[7wzw]] – yChk Mec1 + LCD1 – Cryo EM<br />
 **[[6z2w]], [[6z2x]] – yChk Mec1 (mutant) + LCD1 – Cryo EM<br />
 **[[7kue]] – yChk Kin28 in TFIIK complex – Cryo EM<br />
@@ Line 726: / Line 778: @@
 *Serine/threonine protein kinase Rad53 see [[Rad53]]
+*Serine/threonine protein kinase Gsk3B see [[Glycogen synthase kinase 3]]
 }}
 [[Category:Topic Page]]