7x8j

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(New page: '''Unreleased structure''' The entry 7x8j is ON HOLD Authors: Description: Category: Unreleased Structures)
Current revision (17:49, 29 November 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 7x8j is ON HOLD
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==Arabidopsis GDP-D-mannose pyrophosphorylase (VTC1) structure (unliganded)==
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<StructureSection load='7x8j' size='340' side='right'caption='[[7x8j]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7x8j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7X8J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7X8J FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.798&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7x8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7x8j OCA], [https://pdbe.org/7x8j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7x8j RCSB], [https://www.ebi.ac.uk/pdbsum/7x8j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7x8j ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GMPP1_ARATH GMPP1_ARATH] Essential protein during embryogenesis (PubMed:15266054). Catalyzes a reaction of the Smirnoff-Wheeler pathway, the major route to ascorbate biosynthesis in plants. Plays an essential role in plant growth and development and cell-wall architecture. Provides GDP-mannose, used for cell wall carbohydrate biosynthesis, protein N-glycosylation, as well as for the biosynthesis of the antioxidant ascorbate.<ref>PMID:10097187</ref> <ref>PMID:10655235</ref> <ref>PMID:11226227</ref> <ref>PMID:12671089</ref> <ref>PMID:15064386</ref> <ref>PMID:15266054</ref> <ref>PMID:16244149</ref> <ref>PMID:16720601</ref> <ref>PMID:18849295</ref> <ref>PMID:19011088</ref> <ref>PMID:8790441</ref> <ref>PMID:9390448</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Plant GDP-D-mannose pyrophosphorylase (GMPase) catalyzes a committed step in ascorbic acid biosynthesis pathway. Arabidopsis thaliana VTC1 is the first genetically characterized plant GMPase and has unique properties when compared with bacterial and animal homologs. Here we present the crystal structures of VTC1 in the unliganded and product-bound states at resolutions of 2.8 and 3.0 A, respectively. VTC1 dimerizes in a same way like other known GMPases, but dodecamerizes in a previously unobserved arrangement. The interactions to GDP-D-mannose and inorganic pyrophosphate are revealed by the product-bound VTC1 structure. An in vitro GMPase activity assay confirms the regulatory role of the C-terminal left-handed beta-helix domain, and structural analyses suggest the models of VTC1 hetero-complex with its interacting proteins. The structural information advances our insights into the different mechanisms involved in VTC1 regulation.
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Authors:
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Crystal Structures of Arabidopsis thaliana GDP-D-Mannose Pyrophosphorylase VITAMIN C DEFECTIVE 1.,Zhang C, Zhao S, Li YS, He C, Wang X, Liu L Front Plant Sci. 2022 May 23;13:899738. doi: 10.3389/fpls.2022.899738., eCollection 2022. PMID:35677252<ref>PMID:35677252</ref>
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Description:
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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<div class="pdbe-citations 7x8j" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Arabidopsis thaliana]]
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[[Category: Large Structures]]
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[[Category: Liu L]]
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[[Category: Zhang C]]
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[[Category: Zhao S]]

Current revision

Arabidopsis GDP-D-mannose pyrophosphorylase (VTC1) structure (unliganded)

PDB ID 7x8j

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