We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.
7f3y
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
<StructureSection load='7f3y' size='340' side='right'caption='[[7f3y]], [[Resolution|resolution]] 2.25Å' scene=''> | <StructureSection load='7f3y' size='340' side='right'caption='[[7f3y]], [[Resolution|resolution]] 2.25Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[7f3y]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7F3Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7F3Y FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7f3y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7F3Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7F3Y FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MTX:METHOTREXATE'>MTX</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.252Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MTX:METHOTREXATE'>MTX</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7f3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7f3y OCA], [https://pdbe.org/7f3y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7f3y RCSB], [https://www.ebi.ac.uk/pdbsum/7f3y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7f3y ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7f3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7f3y OCA], [https://pdbe.org/7f3y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7f3y RCSB], [https://www.ebi.ac.uk/pdbsum/7f3y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7f3y ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/DRTS_PLAFK DRTS_PLAFK] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP.[HAMAP-Rule:MF_00008] | |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 23: | Line 24: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Tanramluk, D]] | ||
| - | [[Category: Vanichtanankul, J]] | ||
| - | [[Category: Yuthavong, Y]] | ||
| - | [[Category: Yuvaniyama, J]] | ||
| - | [[Category: Dihydrofolate reductase]] | ||
| - | [[Category: Methotrexate]] | ||
| - | [[Category: Pfdhfr]] | ||
[[Category: Plasmodium falciparum]] | [[Category: Plasmodium falciparum]] | ||
| - | [[Category: | + | [[Category: Tanramluk D]] |
| + | [[Category: Vanichtanankul J]] | ||
| + | [[Category: Yuthavong Y]] | ||
| + | [[Category: Yuvaniyama J]] | ||
Current revision
Wild-type Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with methotrexate (MTX), NADPH and dUMP
| |||||||||||
