7f6v

<table><tr><td colspan='2'>[[7f6v]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7F6V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7F6V FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene></td></tr>

== Function ==

[[https://www.uniprot.org/uniprot/TACAN_HUMAN TACAN_HUMAN]] Ion channel involved in sensing mechanical pain. Contributes to mechanosensitive currents in nocireceptors and detecting mechanical pain stimuli (By similarity). May also be required for efficient adipogenesis (PubMed:26024229).[UniProtKB:Q8C1E7]<ref>PMID:26024229</ref>

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== Publication Abstract from PubMed ==

TACAN is an ion channel-like protein that may be involved in sensing mechanical pain. Here, we present the cryo-electron microscopic structure of human TACAN (hTACAN). hTACAN forms a dimer in which each protomer consists of a transmembrane globular domain (TMD) containing six helices and an intracellular domain (ICD) containing two helices. Molecular dynamic simulations suggest that each protomer contains a putative ion conduction pore. A single-point mutation of the key residue Met207 greatly increases membrane pressure-activated currents. In addition, each hTACAN subunit binds one cholesterol molecule. Our data show the molecular assembly of hTACAN and suggest that wild-type hTACAN is in a closed state.

Cryo-EM structure of the human TACAN in a closed state.,Chen X, Wang Y, Li Y, Lu X, Chen J, Li M, Wen T, Liu N, Chang S, Zhang X, Yang X, Shen Y Cell Rep. 2022 Mar 1;38(9):110445. doi: 10.1016/j.celrep.2022.110445. PMID:35235791<ref>PMID:35235791</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 7f6v" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Chen, X Z]]

[[Category: Li, Y]]

[[Category: Shen, Y Q]]

[[Category: Wang, Y J]]

[[Category: Yang, X]]

[[Category: Membrane protein]]