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1rz8

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CRYSTAL STRUCTURE OF HUMAN ANTI-HIV-1 GP120-REACTIVE ANTIBODY 17B

Structural highlights

1rz8 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.3Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The conserved surface of the HIV-1 gp120 envelope glycoprotein that binds to the HIV-1 coreceptor is protected from humoral recognition by multiple layers of camouflage. Here we present sequence and genomic analyses for 12 antibodies that pierce these defenses and determine the crystal structures of 5. The data reveal mechanisms and atomic-level details for three unusual immune features: posttranslational mimicry of coreceptor by tyrosine sulfation of antibody, an alternative molecular mechanism controlling such sulfation, and highly selective V(H)-gene usage. When confronted by extraordinary viral defenses, the immune system unveils novel adaptive capabilities, with tyrosine sulfation enhancing the vocabulary of antigen recognition.

Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120.,Huang CC, Venturi M, Majeed S, Moore MJ, Phogat S, Zhang MY, Dimitrov DS, Hendrickson WA, Robinson J, Sodroski J, Wyatt R, Choe H, Farzan M, Kwong PD Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2706-11. Epub 2004 Feb 23. PMID:14981267^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Huang CC, Venturi M, Majeed S, Moore MJ, Phogat S, Zhang MY, Dimitrov DS, Hendrickson WA, Robinson J, Sodroski J, Wyatt R, Choe H, Farzan M, Kwong PD. Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120. Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2706-11. Epub 2004 Feb 23. PMID:14981267 doi:http://dx.doi.org/10.1073/pnas.0308527100

1 Structural highlights
2 Evolutionary Conservation
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1rz8"

@@ Line 3: / Line 3: @@
 <StructureSection load='1rz8' size='340' side='right'caption='[[1rz8]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1rz8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RZ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RZ8 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1rz8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RZ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RZ8 FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1rz7|1rz7]], [[1rzf|1rzf]], [[1rzg|1rzg]], [[1rzi|1rzi]], [[1rzj|1rzj]], [[1rzk|1rzk]]</div></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rz8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rz8 OCA], [https://pdbe.org/1rz8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rz8 RCSB], [https://www.ebi.ac.uk/pdbsum/1rz8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rz8 ProSAT]</span></td></tr>
 </table>
@@ Line 35: / Line 35: @@
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Choe, H]]
+[[Category: Choe H]]
-[[Category: Dimitrov, D S]]
+[[Category: Dimitrov DS]]
-[[Category: Farzan, M]]
+[[Category: Farzan M]]
-[[Category: Hendrickson, W A]]
+[[Category: Hendrickson WA]]
-[[Category: Huang, C C]]
+[[Category: Huang CC]]
-[[Category: Kwong, P D]]
+[[Category: Kwong PD]]
-[[Category: Majeed, S]]
+[[Category: Majeed S]]
-[[Category: Moore, M J]]
+[[Category: Moore MJ]]
-[[Category: Phogat, S]]
+[[Category: Phogat S]]
-[[Category: Robinson, J]]
+[[Category: Robinson J]]
-[[Category: Sodroski, J]]
+[[Category: Sodroski J]]
-[[Category: Venturi, M]]
+[[Category: Venturi M]]
-[[Category: Wyatt, R]]
+[[Category: Wyatt R]]
-[[Category: Zhang, M Y]]
+[[Category: Zhang M-Y]]
-[[Category: Antibody]]
-[[Category: Cd4i]]
-[[Category: Gp120]]
-[[Category: Hiv-1]]
-[[Category: Immune system]]
-[[Category: Tyrosine sulfation]]
-[[Category: Vh-gene usage]]

1rz8

From Proteopedia

Current revision

CRYSTAL STRUCTURE OF HUMAN ANTI-HIV-1 GP120-REACTIVE ANTIBODY 17B

Structural highlights

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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