This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1zt4

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:14, 23 August 2023) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='1zt4' size='340' side='right'caption='[[1zt4]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
<StructureSection load='1zt4' size='340' side='right'caption='[[1zt4]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[1zt4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZT4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZT4 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[1zt4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZT4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZT4 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AGH:N-{(1S,2R,3S)-1-[(ALPHA-D-GALACTOPYRANOSYLOXY)METHYL]-2,3-DIHYDROXYHEPTADECYL}HEXACOSANAMIDE'>AGH</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CD1D ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), B2M ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AGH:N-{(1S,2R,3S)-1-[(ALPHA-D-GALACTOPYRANOSYLOXY)METHYL]-2,3-DIHYDROXYHEPTADECYL}HEXACOSANAMIDE'>AGH</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zt4 OCA], [https://pdbe.org/1zt4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zt4 RCSB], [https://www.ebi.ac.uk/pdbsum/1zt4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zt4 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zt4 OCA], [https://pdbe.org/1zt4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zt4 RCSB], [https://www.ebi.ac.uk/pdbsum/1zt4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zt4 ProSAT]</span></td></tr>
</table>
</table>
-
== Disease ==
 
-
[[https://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[https://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
 
== Function ==
== Function ==
-
[[https://www.uniprot.org/uniprot/CD1D_HUMAN CD1D_HUMAN]] Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells.<ref>PMID:17475845</ref> [[https://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
+
[https://www.uniprot.org/uniprot/CD1D_HUMAN CD1D_HUMAN] Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells.<ref>PMID:17475845</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 39: Line 37:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Besra, G S]]
+
[[Category: Besra GS]]
-
[[Category: Cerundolo, V]]
+
[[Category: Cerundolo V]]
-
[[Category: Fersht, A R]]
+
[[Category: Fersht AR]]
-
[[Category: Gadola, S D]]
+
[[Category: Gadola SD]]
-
[[Category: Jones, E Y]]
+
[[Category: Jones EY]]
-
[[Category: Koch, M]]
+
[[Category: Koch M]]
-
[[Category: Mathew, B]]
+
[[Category: Mathew B]]
-
[[Category: Ritter, G]]
+
[[Category: Ritter G]]
-
[[Category: SPINE, Structural Proteomics in Europe]]
+
[[Category: Schmidt RR]]
-
[[Category: Schmidt, R R]]
+
[[Category: Shepherd D]]
-
[[Category: Shepherd, D]]
+
[[Category: Stronge VS]]
-
[[Category: Stronge, V S]]
+
-
[[Category: Alpha-galactosylceramide]]
+
-
[[Category: Alpha-galcer]]
+
-
[[Category: Cd1]]
+
-
[[Category: Empty binding groove]]
+
-
[[Category: Glycolipid]]
+
-
[[Category: Human cd1d]]
+
-
[[Category: Immune system]]
+
-
[[Category: Mhc class i]]
+
-
[[Category: Spine]]
+
-
[[Category: Structural genomic]]
+
-
[[Category: Structural proteomics in europe]]
+

Current revision

The crystal structure of human CD1d with and without alpha-Galactosylceramide

PDB ID 1zt4

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1zt4"
Personal tools