2rtz
From Proteopedia
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==Solution structure of MarkTX-7== | ==Solution structure of MarkTX-7== | ||
| - | <StructureSection load='2rtz' size='340' side='right'caption='[[2rtz | + | <StructureSection load='2rtz' size='340' side='right'caption='[[2rtz]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2rtz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2rtz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mesobuthus_martensii Mesobuthus martensii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RTZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RTZ FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rtz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rtz OCA], [https://pdbe.org/2rtz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rtz RCSB], [https://www.ebi.ac.uk/pdbsum/2rtz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rtz ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rtz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rtz OCA], [https://pdbe.org/2rtz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rtz RCSB], [https://www.ebi.ac.uk/pdbsum/2rtz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rtz ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/KA261_MESMA KA261_MESMA] Recombinant toxin that reversibly inhibits the potassium current of mKv1.3/KCNA3 channel stably expressed in COS7 cells (IC(50)=150 nM) (PubMed:17624312). Also shows a weak inhibition on Kv1.2/KCNA2, Kv1.3/KCNA3 and TRPV1 channels (PubMed:29483648).<ref>PMID:17624312</ref> <ref>PMID:29483648</ref> | ||
==See Also== | ==See Also== | ||
*[[Potassium channel toxin 3D structures|Potassium channel toxin 3D structures]] | *[[Potassium channel toxin 3D structures|Potassium channel toxin 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Buthus martensi]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Mesobuthus martensii]] |
| - | [[Category: | + | [[Category: Ohki S]] |
| - | [[Category: | + | [[Category: Umetsu Y]] |
| - | + | ||
Current revision
Solution structure of MarkTX-7
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