2uw2

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Current revision (09:52, 9 May 2024) (edit) (undo)
 
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<StructureSection load='2uw2' size='340' side='right'caption='[[2uw2]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='2uw2' size='340' side='right'caption='[[2uw2]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2uw2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2iyh 2iyh]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UW2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2UW2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2uw2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2iyh 2iyh]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UW2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2UW2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2iyh|2iyh]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Ribonucleoside-diphosphate_reductase Ribonucleoside-diphosphate reductase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.4.1 1.17.4.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2uw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uw2 OCA], [https://pdbe.org/2uw2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2uw2 RCSB], [https://www.ebi.ac.uk/pdbsum/2uw2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2uw2 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2uw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uw2 OCA], [https://pdbe.org/2uw2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2uw2 RCSB], [https://www.ebi.ac.uk/pdbsum/2uw2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2uw2 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RIR2_HUMAN RIR2_HUMAN] Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Ribonucleoside-diphosphate reductase]]
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[[Category: Arrowsmith C]]
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[[Category: Arrowsmith, C]]
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[[Category: Berglund H]]
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[[Category: Berg, S Van Den]]
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[[Category: Busam R]]
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[[Category: Berglund, H]]
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[[Category: Collins R]]
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[[Category: Busam, R]]
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[[Category: Edwards A]]
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[[Category: Collins, R]]
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[[Category: Ehn M]]
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[[Category: Edwards, A]]
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[[Category: Flodin S]]
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[[Category: Ehn, M]]
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[[Category: Flores A]]
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[[Category: Flodin, S]]
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[[Category: Graslund S]]
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[[Category: Flores, A]]
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[[Category: Hallberg BM]]
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[[Category: Graslund, S]]
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[[Category: Hammarstrom M]]
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[[Category: Hallberg, B M]]
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[[Category: Hogbom M]]
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[[Category: Hammarstrom, M]]
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[[Category: Holmberg Schiavone L]]
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[[Category: Hogbom, M]]
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[[Category: Kotenyova T]]
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[[Category: Kotenyova, T]]
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[[Category: Magnusdottir A]]
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[[Category: Magnusdottir, A]]
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[[Category: Moche M]]
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[[Category: Moche, M]]
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[[Category: Nilsson-Ehle P]]
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[[Category: Nilsson-Ehle, P]]
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[[Category: Nordlund P]]
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[[Category: Nordlund, P]]
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[[Category: Nyman T]]
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[[Category: Nyman, T]]
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[[Category: Ogg D]]
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[[Category: Ogg, D]]
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[[Category: Persson C]]
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[[Category: Persson, C]]
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[[Category: Sagemark J]]
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[[Category: Sagemark, J]]
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[[Category: Stenmark P]]
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[[Category: Schiavone, L Holmberg]]
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[[Category: Sundstrom M]]
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[[Category: Stenmark, P]]
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[[Category: Thorsell AG]]
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[[Category: Sundstrom, M]]
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[[Category: Uppenberg J]]
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[[Category: Thorsell, A G]]
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[[Category: Van Den Berg S]]
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[[Category: Uppenberg, J]]
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[[Category: Wallden K]]
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[[Category: Wallden, K]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J]]
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[[Category: Welin M]]
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[[Category: Welin, M]]
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[[Category: Diiron]]
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[[Category: Dna replication]]
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[[Category: Iron]]
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[[Category: Metal-binding]]
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[[Category: Oxidoreductase]]
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[[Category: Phosphorylation]]
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[[Category: R2]]
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[[Category: R2 subunit]]
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[[Category: Radical]]
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[[Category: Ribonucleotide reductase]]
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[[Category: Small subunit ribonucleotide reductase]]
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Current revision

Crystal structure of human ribonucleotide reductase subunit R2

PDB ID 2uw2

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

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