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3hjw

From Proteopedia

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Current revision (07:22, 6 September 2023) (edit) (undo)
 
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<StructureSection load='3hjw' size='340' side='right'caption='[[3hjw]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
<StructureSection load='3hjw' size='340' side='right'caption='[[3hjw]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3hjw]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_43587 Atcc 43587]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HJW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HJW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3hjw]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HJW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HJW FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=FHU:(5S,6R)-5-FLUORO-6-HYDROXY-PSEUDOURIDINE-5-MONOPHOSPHATE'>FHU</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FHU:(5S,6R)-5-FLUORO-6-HYDROXY-PSEUDOURIDINE-5-MONOPHOSPHATE'>FHU</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3hjy|3hjy]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PF1785 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2261 ATCC 43587]), PF1141 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2261 ATCC 43587]), PF1367, rpl7ae ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2261 ATCC 43587])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hjw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hjw OCA], [https://pdbe.org/3hjw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hjw RCSB], [https://www.ebi.ac.uk/pdbsum/3hjw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hjw ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hjw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hjw OCA], [https://pdbe.org/3hjw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hjw RCSB], [https://www.ebi.ac.uk/pdbsum/3hjw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hjw ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/TRUB_PYRFU TRUB_PYRFU]] Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs (By similarity). [[https://www.uniprot.org/uniprot/RL7A_PYRFU RL7A_PYRFU]] Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, box H/ACA, box C/D and box C'/D' sRNAs (By similarity). [[https://www.uniprot.org/uniprot/NOP10_PYRFU NOP10_PYRFU]] Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA (By similarity).
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[https://www.uniprot.org/uniprot/TRUB_PYRFU TRUB_PYRFU] Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Atcc 43587]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Kahen, E]]
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[[Category: Pyrococcus furiosus]]
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[[Category: Li, H]]
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[[Category: Kahen E]]
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[[Category: Liang, B]]
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[[Category: Li H]]
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[[Category: Terns, M P]]
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[[Category: Liang B]]
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[[Category: Terns, R M]]
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[[Category: Terns MP]]
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[[Category: Zhou, J]]
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[[Category: Terns RM]]
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[[Category: Box h/aca]]
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[[Category: Zhou J]]
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[[Category: Isomerase]]
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[[Category: Isomerase-rna complex]]
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[[Category: Post-transcriptional modification]]
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[[Category: Protein-rna complex]]
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[[Category: Pseudouridine synthase]]
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[[Category: Pseudouridylase]]
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[[Category: Pseudouridylation]]
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[[Category: Ribonucleoprotein]]
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[[Category: Ribonucleoprotein particle]]
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[[Category: Ribosomal protein]]
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[[Category: Ribosome biogenesis]]
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[[Category: Rna editing]]
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[[Category: Rna-binding]]
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[[Category: Rnp]]
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[[Category: Rrna processing]]
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[[Category: Trna processing]]
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Current revision

Structure of a functional ribonucleoprotein pseudouridine synthase bound to a substrate RNA

PDB ID 3hjw

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