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1gqe

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[[Image:1gqe.gif|left|200px]]
 
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==Polypeptide Chain Release Factor 2 (RF2) from Escherichia coli==
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The line below this paragraph, containing "STRUCTURE_1gqe", creates the "Structure Box" on the page.
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<StructureSection load='1gqe' size='340' side='right'caption='[[1gqe]], [[Resolution|resolution]] 1.81&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1gqe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GQE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GQE FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.81&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_1gqe| PDB=1gqe | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gqe OCA], [https://pdbe.org/1gqe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gqe RCSB], [https://www.ebi.ac.uk/pdbsum/1gqe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gqe ProSAT]</span></td></tr>
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</table>
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'''POLYPEPTIDE CHAIN RELEASE FACTOR 2 (RF2) FROM ESCHERICHIA COLI'''
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== Function ==
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[https://www.uniprot.org/uniprot/RF2_ECOLI RF2_ECOLI] Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.[HAMAP-Rule:MF_00094]
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== Evolutionary Conservation ==
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==Overview==
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[[Image:Consurf_key_small.gif|200px|right]]
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Bacterial release factor RF2 promotes termination of protein synthesis, specifically recognizing stop codons UAA or UGA. The crystal structure of Escherichia coli RF2 has been determined to a resolution of 1.8 A. RF2 is structurally distinct from its eukaryotic counterpart eRF1. The tripeptide SPF motif, thought to confer RF2 stop codon specificity, and the universally conserved GGQ motif, proposed to be involved with the peptidyl transferase center, are exposed in loops only 23 A apart, and the structure suggests that stop signal recognition is more complex than generally believed.
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gq/1gqe_consurf.spt"</scriptWhenChecked>
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1GQE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GQE OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==Reference==
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</jmolCheckbox>
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Bacterial polypeptide release factor RF2 is structurally distinct from eukaryotic eRF1., Vestergaard B, Van LB, Andersen GR, Nyborg J, Buckingham RH, Kjeldgaard M, Mol Cell. 2001 Dec;8(6):1375-82. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11779511 11779511]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gqe ConSurf].
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[[Category: Escherichia coli]]
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<div style="clear:both"></div>
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[[Category: Single protein]]
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__TOC__
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[[Category: Kjeldgaard, M.]]
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</StructureSection>
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[[Category: Vestergaard, B.]]
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[[Category: Escherichia coli K-12]]
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[[Category: Macromolecular mimicry]]
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[[Category: Large Structures]]
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[[Category: Protein synthesis]]
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[[Category: Kjeldgaard M]]
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[[Category: Ribosome]]
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[[Category: Vestergaard B]]
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[[Category: Translation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:53:25 2008''
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Current revision

Polypeptide Chain Release Factor 2 (RF2) from Escherichia coli

PDB ID 1gqe

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