7qo8
From Proteopedia
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==Structure of Protease1 from Pyrococcus horikoshii in space group 19 with a hexamer in the asymmetric unit== | ==Structure of Protease1 from Pyrococcus horikoshii in space group 19 with a hexamer in the asymmetric unit== | ||
| - | <StructureSection load='7qo8' size='340' side='right'caption='[[7qo8]]' scene=''> | + | <StructureSection load='7qo8' size='340' side='right'caption='[[7qo8]], [[Resolution|resolution]] 1.95Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QO8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QO8 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7qo8]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QO8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QO8 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qo8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qo8 OCA], [https://pdbe.org/7qo8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qo8 RCSB], [https://www.ebi.ac.uk/pdbsum/7qo8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qo8 ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qo8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qo8 OCA], [https://pdbe.org/7qo8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qo8 RCSB], [https://www.ebi.ac.uk/pdbsum/7qo8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qo8 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DEGLY_PYRHO DEGLY_PYRHO] Deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins and reactive carbonyl groups of glyoxals. Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) that cause irreversible damage (By similarity). Also displays proteolytic activity (PubMed:11114201).[UniProtKB:Q51732]<ref>PMID:11114201</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| + | [[Category: Pyrococcus horikoshii]] | ||
[[Category: Engilberge S]] | [[Category: Engilberge S]] | ||
[[Category: Gabel F]] | [[Category: Gabel F]] | ||
[[Category: Girard E]] | [[Category: Girard E]] | ||
Current revision
Structure of Protease1 from Pyrococcus horikoshii in space group 19 with a hexamer in the asymmetric unit
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