7ved
From Proteopedia
(Difference between revisions)
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==Crystal structure of GABARAP fused to TEX264 LIR with S272D mutation== | ==Crystal structure of GABARAP fused to TEX264 LIR with S272D mutation== | ||
| - | <StructureSection load='7ved' size='340' side='right'caption='[[7ved]]' scene=''> | + | <StructureSection load='7ved' size='340' side='right'caption='[[7ved]], [[Resolution|resolution]] 2.02Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VED OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VED FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7ved]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VED OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VED FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ved FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ved OCA], [https://pdbe.org/7ved PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ved RCSB], [https://www.ebi.ac.uk/pdbsum/7ved PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ved ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.02Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ved FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ved OCA], [https://pdbe.org/7ved PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ved RCSB], [https://www.ebi.ac.uk/pdbsum/7ved PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ved ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GBRAP_HUMAN GBRAP_HUMAN] May play a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in apoptosis. Involved in autophagy (By similarity).<ref>PMID:15977068</ref> [https://www.uniprot.org/uniprot/TX264_HUMAN TX264_HUMAN] Major reticulophagy (also called ER-phagy) receptor that acts independently of other candidate reticulophagy receptors to remodel subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006538, PubMed:31006537). The ATG8-containing isolation membrane (IM) cradles a tubular segment of TEX264-positive ER near a three-way junction, allowing the formation of a synapse of 2 juxtaposed membranes with trans interaction between the TEX264 and ATG8 proteins (PubMed:31006537). Expansion of the IM would extend the capture of ER, possibly through a 'zipper-like' process involving continued trans TEX264-ATG8 interactions, until poorly understood mechanisms lead to the fission of relevant membranes and, ultimately, autophagosomal membrane closure (PubMed:31006537). Also involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis: acts by bridging VCP/p97 to covalent DNA-protein cross-links (DPCs) and initiating resolution of DPCs by SPRTN (PubMed:32152270).<ref>PMID:31006537</ref> <ref>PMID:31006538</ref> <ref>PMID:32152270</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Noda NN]] | [[Category: Noda NN]] | ||
[[Category: Yamasaki A]] | [[Category: Yamasaki A]] | ||
Current revision
Crystal structure of GABARAP fused to TEX264 LIR with S272D mutation
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