6rz9
From Proteopedia
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<StructureSection load='6rz9' size='340' side='right'caption='[[6rz9]], [[Resolution|resolution]] 2.73Å' scene=''> | <StructureSection load='6rz9' size='340' side='right'caption='[[6rz9]], [[Resolution|resolution]] 2.73Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
- | <table><tr><td colspan='2'>[[6rz9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[6rz9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RZ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RZ9 FirstGlance]. <br> |
- | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=KO5:(2~{S})-8-[[4-[4-(5-fluoranyl-2-methyl-phenyl)butoxy]phenyl]carbonylamino]-4-(4-oxidanyl-4-oxidanylidene-butyl)-2,3- | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.73Å</td></tr> |
- | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=KO5:(2~{S})-8-[[4-[4-(5-fluoranyl-2-methyl-phenyl)butoxy]phenyl]carbonylamino]-4-(4-oxidanyl-4-oxidanylidene-butyl)-2,3-dihydro-1,4-benzoxazine-2-carboxylic+acid'>KO5</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene></td></tr> | |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rz9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rz9 OCA], [https://pdbe.org/6rz9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rz9 RCSB], [https://www.ebi.ac.uk/pdbsum/6rz9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rz9 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rz9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rz9 OCA], [https://pdbe.org/6rz9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rz9 RCSB], [https://www.ebi.ac.uk/pdbsum/6rz9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rz9 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
- | + | [https://www.uniprot.org/uniprot/CLTR2_HUMAN CLTR2_HUMAN] Uveal melanoma. | |
== Function == | == Function == | ||
- | [[https://www.uniprot.org/uniprot/CLTR2_HUMAN CLTR2_HUMAN | + | [https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.[https://www.uniprot.org/uniprot/CLTR2_HUMAN CLTR2_HUMAN] Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4. |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
- | [[Category: | + | [[Category: Escherichia coli]] |
+ | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
- | [[Category: Besserer-Offroy | + | [[Category: Besserer-Offroy E]] |
- | [[Category: Borshchevskiy | + | [[Category: Borshchevskiy V]] |
- | [[Category: Brouillette | + | [[Category: Brouillette RL]] |
- | [[Category: Cherezov | + | [[Category: Cherezov V]] |
- | [[Category: Ergasheva | + | [[Category: Ergasheva M]] |
- | [[Category: Fujimoto | + | [[Category: Fujimoto T]] |
- | [[Category: Gordeliy | + | [[Category: Gordeliy V]] |
- | [[Category: Gusach | + | [[Category: Gusach A]] |
- | [[Category: Han | + | [[Category: Han GW]] |
- | [[Category: Ishchenko | + | [[Category: Ishchenko A]] |
- | [[Category: Katritch | + | [[Category: Katritch V]] |
- | [[Category: Kovalev | + | [[Category: Kovalev K]] |
- | [[Category: Longpre | + | [[Category: Longpre JM]] |
- | [[Category: Luginina | + | [[Category: Luginina A]] |
- | [[Category: Marin | + | [[Category: Marin E]] |
- | [[Category: Maruyama | + | [[Category: Maruyama T]] |
- | [[Category: Mishin | + | [[Category: Mishin A]] |
- | [[Category: Popov | + | [[Category: Popov P]] |
- | [[Category: Romanovskaya | + | [[Category: Romanovskaya D]] |
- | [[Category: Sarret | + | [[Category: Sarret P]] |
- | [[Category: Shevtsov | + | [[Category: Shevtsov M]] |
- | [[Category: Stauch | + | [[Category: Stauch B]] |
- | [[Category: Stepko | + | [[Category: Stepko A]] |
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Current revision
Crystal structure of the human cysteinyl leukotriene receptor 2 in complex with ONO-2770372
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Categories: Escherichia coli | Homo sapiens | Large Structures | Besserer-Offroy E | Borshchevskiy V | Brouillette RL | Cherezov V | Ergasheva M | Fujimoto T | Gordeliy V | Gusach A | Han GW | Ishchenko A | Katritch V | Kovalev K | Longpre JM | Luginina A | Marin E | Maruyama T | Mishin A | Popov P | Romanovskaya D | Sarret P | Shevtsov M | Stauch B | Stepko A