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6thg

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Current revision (13:02, 24 January 2024) (edit) (undo)
 
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<StructureSection load='6thg' size='340' side='right'caption='[[6thg]], [[Resolution|resolution]] 4.07&Aring;' scene=''>
<StructureSection load='6thg' size='340' side='right'caption='[[6thg]], [[Resolution|resolution]] 4.07&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6thg]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Cedpv Cedpv] and [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6THG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6THG FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6thg]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Cedar_virus Cedar virus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6THG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6THG FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.074&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[6thb|6thb]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">EFNB1, EFL3, EPLG2, LERK2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6thg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6thg OCA], [https://pdbe.org/6thg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6thg RCSB], [https://www.ebi.ac.uk/pdbsum/6thg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6thg ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6thg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6thg OCA], [https://pdbe.org/6thg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6thg RCSB], [https://www.ebi.ac.uk/pdbsum/6thg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6thg ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
 
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[[https://www.uniprot.org/uniprot/EFNB1_HUMAN EFNB1_HUMAN]] Craniofrontonasal dysplasia. The disease is caused by mutations affecting the gene represented in this entry.
 
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/EFNB1_HUMAN EFNB1_HUMAN]] Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development (PubMed:8070404, PubMed:7973638). Binding to Eph receptors residing on adjacent cells leads to contact-dependent bidirectional signaling into neighboring cells (PubMed:8070404, PubMed:7973638). Shows high affinity for the receptor tyrosine kinase EPHB1/ELK (PubMed:8070404, PubMed:7973638). Can also bind EPHB2 and EPHB3 (PubMed:8070404). Binds to, and induces collapse of, commissural axons/growth cones in vitro (By similarity). May play a role in constraining the orientation of longitudinally projecting axons (By similarity).[UniProtKB:P52795]<ref>PMID:7973638</ref> <ref>PMID:8070404</ref>
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[https://www.uniprot.org/uniprot/J7H333_9MONO J7H333_9MONO]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cedpv]]
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[[Category: Cedar virus]]
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bowden, T]]
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[[Category: Bowden T]]
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[[Category: Harlos, K]]
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[[Category: Harlos K]]
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[[Category: Pryce, R]]
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[[Category: Pryce R]]
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[[Category: Rissanen, I]]
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[[Category: Rissanen I]]
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[[Category: Attachment glycoprotein]]
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[[Category: Beta-propeller]]
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[[Category: Complex]]
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[[Category: Ephrin-b1]]
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[[Category: Viral protein]]
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Current revision

Cedar Virus attachment glycoprotein (G) in complex with human ephrin-B1

PDB ID 6thg

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OCA

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