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2vr2
From Proteopedia
(Difference between revisions)
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<StructureSection load='2vr2' size='340' side='right'caption='[[2vr2]], [[Resolution|resolution]] 2.80Å' scene=''> | <StructureSection load='2vr2' size='340' side='right'caption='[[2vr2]], [[Resolution|resolution]] 2.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2vr2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2vr2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VR2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VR2 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vr2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vr2 OCA], [https://pdbe.org/2vr2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vr2 RCSB], [https://www.ebi.ac.uk/pdbsum/2vr2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vr2 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vr2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vr2 OCA], [https://pdbe.org/2vr2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vr2 RCSB], [https://www.ebi.ac.uk/pdbsum/2vr2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vr2 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/DPYS_HUMAN DPYS_HUMAN] Dihydropyrimidinuria. The disease is caused by variants affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DPYS_HUMAN DPYS_HUMAN] Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6-dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | + | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Andersson | + | [[Category: Andersson J]] |
| - | [[Category: Arrowsmith | + | [[Category: Arrowsmith CH]] |
| - | + | [[Category: Berglund H]] | |
| - | [[Category: Berglund | + | [[Category: Busam RD]] |
| - | [[Category: Busam | + | [[Category: Collins R]] |
| - | [[Category: Collins | + | [[Category: Dahlgren LG]] |
| - | [[Category: Dahlgren | + | [[Category: Edwards AM]] |
| - | [[Category: Edwards | + | [[Category: Flodin S]] |
| - | [[Category: Flodin | + | [[Category: Flores A]] |
| - | [[Category: Flores | + | [[Category: Graslund S]] |
| - | [[Category: Graslund | + | [[Category: Hammarstrom M]] |
| - | [[Category: Hammarstrom | + | [[Category: Herman MD]] |
| - | [[Category: Herman | + | [[Category: Johansson I]] |
| - | [[Category: Johansson | + | [[Category: Kallas A]] |
| - | [[Category: Kallas | + | [[Category: Karlberg T]] |
| - | [[Category: Karlberg | + | [[Category: Kotenyova T]] |
| - | [[Category: Kotenyova | + | [[Category: Lehtio L]] |
| - | [[Category: Lehtio | + | [[Category: Moche M]] |
| - | [[Category: Moche | + | [[Category: Nilsson ME]] |
| - | [[Category: Nilsson | + | [[Category: Nordlund P]] |
| - | [[Category: Nordlund | + | [[Category: Nyman T]] |
| - | [[Category: Nyman | + | [[Category: Persson C]] |
| - | [[Category: Persson | + | [[Category: Sagemark J]] |
| - | + | [[Category: Svensson L]] | |
| - | [[Category: Sagemark | + | [[Category: Thorsell AG]] |
| - | [[Category: Svensson | + | [[Category: Tresaugues L]] |
| - | [[Category: Thorsell | + | [[Category: Van Den Berg S]] |
| - | [[Category: Tresaugues | + | [[Category: Weigelt J]] |
| - | [[Category: | + | [[Category: Welin M]] |
| - | [[Category: | + | [[Category: Wikstrom M]] |
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Current revision
Human Dihydropyrimidinase
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Categories: Homo sapiens | Large Structures | Andersson J | Arrowsmith CH | Berglund H | Busam RD | Collins R | Dahlgren LG | Edwards AM | Flodin S | Flores A | Graslund S | Hammarstrom M | Herman MD | Johansson I | Kallas A | Karlberg T | Kotenyova T | Lehtio L | Moche M | Nilsson ME | Nordlund P | Nyman T | Persson C | Sagemark J | Svensson L | Thorsell AG | Tresaugues L | Van Den Berg S | Weigelt J | Welin M | Wikstrom M
