2vya

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (15:37, 13 December 2023) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='2vya' size='340' side='right'caption='[[2vya]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
<StructureSection load='2vya' size='340' side='right'caption='[[2vya]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[2vya]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VYA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VYA FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[2vya]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VYA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VYA FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PF7:4-(QUINOLIN-3-YLMETHYL)PIPERIDINE-1-CARBOXYLIC+ACID'>PF7</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1mt5|1mt5]]</div></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PF7:4-(QUINOLIN-3-YLMETHYL)PIPERIDINE-1-CARBOXYLIC+ACID'>PF7</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Amidase Amidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.4 3.5.1.4] </span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vya OCA], [https://pdbe.org/2vya PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vya RCSB], [https://www.ebi.ac.uk/pdbsum/2vya PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vya ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vya OCA], [https://pdbe.org/2vya PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vya RCSB], [https://www.ebi.ac.uk/pdbsum/2vya PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vya ProSAT]</span></td></tr>
</table>
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/FAAH1_RAT FAAH1_RAT] Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 35: Line 36:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Amidase]]
 
-
[[Category: Buffalo rat]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Ahn, K]]
+
[[Category: Rattus norvegicus]]
-
[[Category: Bhattacharya, K]]
+
[[Category: Ahn K]]
-
[[Category: Cravatt, B F]]
+
[[Category: Bhattacharya K]]
-
[[Category: Everdeen, D S]]
+
[[Category: Cravatt BF]]
-
[[Category: Johnson, D S]]
+
[[Category: Everdeen DS]]
-
[[Category: Kamtekar, S]]
+
[[Category: Johnson DS]]
-
[[Category: Liimatta, M]]
+
[[Category: Kamtekar S]]
-
[[Category: Mileni, M]]
+
[[Category: Liimatta M]]
-
[[Category: Nugent, R A]]
+
[[Category: Mileni M]]
-
[[Category: Pabst, B]]
+
[[Category: Nugent RA]]
-
[[Category: Stevens, R C]]
+
[[Category: Pabst B]]
-
[[Category: Wang, Z]]
+
[[Category: Stevens RC]]
-
[[Category: Chimera]]
+
[[Category: Wang Z]]
-
[[Category: Covalent]]
+
-
[[Category: Drug- like]]
+
-
[[Category: Endoplasmic reticulum]]
+
-
[[Category: Faah]]
+
-
[[Category: Fatty acid amide hydrolyse]]
+
-
[[Category: Golgi apparatus]]
+
-
[[Category: Humanized]]
+
-
[[Category: Hydrolase]]
+
-
[[Category: Inhibitor]]
+
-
[[Category: Membrane]]
+
-
[[Category: Transmembrane]]
+

Current revision

Crystal Structure of fatty acid amide hydrolase conjugated with the drug-like inhibitor PF-750

PDB ID 2vya

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2vya"
Personal tools