MTOR signaling pathway
From Proteopedia
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<StructureSection load='' size='340' side='right' caption='' scene='90/908701/Rapamycin/1'> | <StructureSection load='' size='340' side='right' caption='' scene='90/908701/Rapamycin/1'> | ||
| - | '''mTOR''' (mammalian target of [[Rapamycin]]) integrates the input from insulin, growth factors and amino acids. [[Rapamycin]] inhibits mTOR by association with FKBP12<ref>PMID:22500797</ref>. | + | '''mTOR''' (mammalian target of [[Rapamycin]]) integrates the input from insulin, growth factors and amino acids. [[Rapamycin]] inhibits mTOR by association with FKBP12<ref>PMID:22500797</ref>. '''mTOR''' functions as a [[serine/threonine protein kinase]] that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis, autophagy, and transcription. |
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Current revision
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References
- ↑ Laplante M, Sabatini DM. mTOR signaling in growth control and disease. Cell. 2012 Apr 13;149(2):274-93. doi: 10.1016/j.cell.2012.03.017. PMID:22500797 doi:http://dx.doi.org/10.1016/j.cell.2012.03.017
