7u4j

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'''Unreleased structure'''
 
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The entry 7u4j is ON HOLD until Paper Publication
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==Crystal structure of human GPX4-U46C-R152H in complex with TMT10==
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<StructureSection load='7u4j' size='340' side='right'caption='[[7u4j]], [[Resolution|resolution]] 1.81&Aring;' scene=''>
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Authors: Forouhar, F., Liu, H., Lin, A.J., Wang, Q., Xia, X., Stockwell, B.R.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7u4j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7U4J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7U4J FirstGlance]. <br>
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Description: Crystal structure of human GPX4-U46C-R152H in complex with TMT10
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.81&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8NB:~{N}-(3-CHLORANYL-4-METHOXY-PHENYL)ETHANAMIDE'>8NB</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
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[[Category: Forouhar, F]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7u4j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7u4j OCA], [https://pdbe.org/7u4j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7u4j RCSB], [https://www.ebi.ac.uk/pdbsum/7u4j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7u4j ProSAT]</span></td></tr>
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[[Category: Wang, Q]]
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</table>
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[[Category: Lin, A.J]]
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== Function ==
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[[Category: Xia, X]]
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[https://www.uniprot.org/uniprot/GPX4_HUMAN GPX4_HUMAN] Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage (By similarity).
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[[Category: Liu, H]]
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__TOC__
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[[Category: Stockwell, B.R]]
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Forouhar F]]
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[[Category: Lin AJ]]
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[[Category: Liu H]]
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[[Category: Polychronidou V]]
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[[Category: Soni RK]]
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[[Category: Stockwell BR]]
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[[Category: Wang Q]]
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[[Category: Xia X]]

Current revision

Crystal structure of human GPX4-U46C-R152H in complex with TMT10

PDB ID 7u4j

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