7z9l
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Phen-DC3 intercalation causes hybrid-to-antiparallel transformation of human telomeric DNA G-quadruplex== | |
| + | <StructureSection load='7z9l' size='340' side='right'caption='[[7z9l]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[7z9l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Z9L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Z9L FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PQ3:N2,N9-BIS(1-METHYLQUINOLIN-3-YL)-1,10-PHENANTHROLINE-2,9-DICARBOXAMIDE'>PQ3</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7z9l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7z9l OCA], [https://pdbe.org/7z9l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7z9l RCSB], [https://www.ebi.ac.uk/pdbsum/7z9l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7z9l ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Human telomeric G-quadruplex DNA structures are attractive anticancer drug targets, but the target's polymorphism complicates the drug design: different ligands prefer different folds, and very few complexes have been solved at high resolution. Here we report that Phen-DC3 , one of the most prominent G-quadruplex ligands in terms of high binding affinity and selectivity, causes dTAGGG(TTAGGG)3 to completely change its fold in KCl solution from a hybrid-1 to an antiparallel chair-type structure, wherein the ligand intercalates between a two-quartet unit and a pseudo-quartet, thereby ejecting one potassium ion. This unprecedented high-resolution NMR structure shows for the first time a true ligand intercalation into an intramolecular G-quadruplex. | ||
| - | + | Phen-DC3 Induces Refolding of Human Telomeric DNA into a Chair-Type Antiparallel G-Quadruplex through Ligand Intercalation.,Ghosh A, Trajkovski M, Teulade-Fichou MP, Gabelica V, Plavec J Angew Chem Int Ed Engl. 2022 Aug 22:e202207384. doi: 10.1002/anie.202207384. PMID:35993443<ref>PMID:35993443</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 7z9l" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Gabelica V]] | ||
| + | [[Category: Ghosh A]] | ||
| + | [[Category: Plavec J]] | ||
| + | [[Category: Teulade-Fichou MP]] | ||
| + | [[Category: Trajkovski M]] | ||
Current revision
Phen-DC3 intercalation causes hybrid-to-antiparallel transformation of human telomeric DNA G-quadruplex
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