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7zej
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 7zej is ON HOLD Authors: Shafqat, N., Yue, W.W., Koekemoer, L., Niesen, F., Ugochukwu, E., Vollmar, M., Weigelt, J., Krojer, T., Pike, A., Chaikaud,...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the human MGC45594 gene product in complex with celecoxib.== | |
| - | + | <StructureSection load='7zej' size='340' side='right'caption='[[7zej]], [[Resolution|resolution]] 1.79Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7zej]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZEJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZEJ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.79Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CEL:4-[5-(4-METHYLPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE'>CEL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zej FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zej OCA], [https://pdbe.org/7zej PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zej RCSB], [https://www.ebi.ac.uk/pdbsum/7zej PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zej ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/PTGR3_HUMAN PTGR3_HUMAN] Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest efficiency towards 15-keto-PGE2-alpha. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation.[UniProtKB:Q8BGC4] |
| - | [[Category: Koekemoer | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Arrowsmith C]] |
| - | [[Category: | + | [[Category: Bountra C]] |
| - | [[Category: | + | [[Category: Chaikaud A]] |
| - | [[Category: | + | [[Category: Edwards A]] |
| - | [[Category: | + | [[Category: Koekemoer L]] |
| - | [[Category: | + | [[Category: Krojer T]] |
| - | [[Category: | + | [[Category: Niesen F]] |
| + | [[Category: Opperman U]] | ||
| + | [[Category: Pike A]] | ||
| + | [[Category: Shafqat N]] | ||
| + | [[Category: Ugochukwu E]] | ||
| + | [[Category: Vollmar M]] | ||
| + | [[Category: Von Delft F]] | ||
| + | [[Category: Weigelt J]] | ||
| + | [[Category: Yue WW]] | ||
Current revision
Crystal structure of the human MGC45594 gene product in complex with celecoxib.
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Categories: Homo sapiens | Large Structures | Arrowsmith C | Bountra C | Chaikaud A | Edwards A | Koekemoer L | Krojer T | Niesen F | Opperman U | Pike A | Shafqat N | Ugochukwu E | Vollmar M | Von Delft F | Weigelt J | Yue WW
