7pyr

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<StructureSection load='7pyr' size='340' side='right'caption='[[7pyr]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='7pyr' size='340' side='right'caption='[[7pyr]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7pyr]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PYR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PYR FirstGlance]. <br>
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PYR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PYR FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8IM:2-[2-[2-[2-[2-[2-[4-[4-[2-[7-azanyl-4-(furan-2-yl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.0^{2,6}]dodeca-1(9),2,4,7,11-pentaen-10-yl]ethyl]piperazin-1-yl]phenoxy]ethanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]-~{N}-[5-[2,2-bis(fluoranyl)-4,6,10,12-tetramethyl-1,3-diaza-2$l^{4}-boratricyclo[7.3.0.0^{3,7}]dodeca-4,6,9,11-tetraen-8-yl]pentyl]ethanamide'>8IM</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8IM:2-[2-[2-[2-[2-[2-[4-[4-[2-[7-azanyl-4-(furan-2-yl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.0^{2,6}]dodeca-1(9),2,4,7,11-pentaen-10-yl]ethyl]piperazin-1-yl]phenoxy]ethanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]-~{N}-[5-[2,2-bis(fluoranyl)-4,6,10,12-tetramethyl-1,3-diaza-2$l^{4}-boratricyclo[7.3.0.0^{3,7}]dodeca-4,6,9,11-tetraen-8-yl]pentyl]ethanamide'>8IM</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7pyr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7pyr OCA], [https://pdbe.org/7pyr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7pyr RCSB], [https://www.ebi.ac.uk/pdbsum/7pyr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7pyr ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7pyr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7pyr OCA], [https://pdbe.org/7pyr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7pyr RCSB], [https://www.ebi.ac.uk/pdbsum/7pyr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7pyr ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
 
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[[https://www.uniprot.org/uniprot/AA2AR_HUMAN AA2AR_HUMAN]] Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
 
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 7pyr" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 7pyr" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Adenosine A2A receptor 3D structures|Adenosine A2A receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Claff, T]]
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[[Category: Claff T]]
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[[Category: Klapschinski, T A]]
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[[Category: Klapschinski TA]]
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[[Category: Labahn, J]]
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[[Category: Labahn J]]
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[[Category: Muller, C E]]
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[[Category: Muller CE]]
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[[Category: Schlegel, J G]]
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[[Category: Schlegel JG]]
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[[Category: Subhramanyam, U K.Tiruttani]]
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[[Category: Tiruttani Subhramanyam UK]]
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[[Category: Vaassen, V J]]
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[[Category: Vaassen VJ]]
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[[Category: Vielmuth, C]]
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[[Category: Vielmuth C]]
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[[Category: Voss, J H]]
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[[Category: Voss JH]]
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[[Category: A2a]]
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[[Category: Adenosine receptor]]
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[[Category: G protein-coupled receptor]]
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[[Category: Gpcr]]
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[[Category: Membrane protein]]
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[[Category: Preladenant]]
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Current revision

Crystal structure of the adenosine A2A receptor (A2A-PSB1-bRIL) in complex with preladenant conjugate PSB-2115

PDB ID 7pyr

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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