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3i1h

From Proteopedia

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Current revision (07:36, 6 September 2023) (edit) (undo)
 
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<StructureSection load='3i1h' size='340' side='right'caption='[[3i1h]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='3i1h' size='340' side='right'caption='[[3i1h]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3i1h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I1H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3I1H FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3i1h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I1H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3I1H FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BCL2A1, BCL2L5, BFL1, GRS, HBPA1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3i1h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i1h OCA], [https://pdbe.org/3i1h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3i1h RCSB], [https://www.ebi.ac.uk/pdbsum/3i1h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3i1h ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3i1h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i1h OCA], [https://pdbe.org/3i1h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3i1h RCSB], [https://www.ebi.ac.uk/pdbsum/3i1h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3i1h ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/B2LA1_HUMAN B2LA1_HUMAN]] Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection (By similarity). [[https://www.uniprot.org/uniprot/BAK_HUMAN BAK_HUMAN]] In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti-apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis.<ref>PMID:8521816</ref> <ref>PMID:17157251</ref>
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[https://www.uniprot.org/uniprot/B2LA1_HUMAN B2LA1_HUMAN] Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
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== References ==
 
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<references/>
 
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Acton, T]]
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[[Category: Acton T]]
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[[Category: Gelinas, C]]
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[[Category: Gelinas C]]
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[[Category: Guan, R]]
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[[Category: Guan R]]
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[[Category: Montelione, G T]]
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[[Category: Montelione GT]]
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[[Category: Structural genomic]]
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[[Category: White E]]
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[[Category: White, E]]
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[[Category: Xiao R]]
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[[Category: Xiao, R]]
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[[Category: Zhao L]]
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[[Category: Zhao, L]]
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[[Category: Apoptosis]]
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[[Category: Bak bh3]]
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[[Category: Bcl-2 family]]
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[[Category: Bfl-1]]
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[[Category: Complex]]
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[[Category: Membrane]]
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[[Category: Metal-binding]]
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[[Category: Nesg]]
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[[Category: Pro-survival protein]]
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[[Category: PSI, Protein structure initiative]]
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[[Category: Transmembrane]]
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Current revision

Crystal structure of human BFL-1 in complex with BAK BH3 peptide

PDB ID 3i1h

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