Son of sevenless

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Mutations in SOS1 have been reported in Noonan syndrome and in type 1 hereditary gingival fibromatosis<ref>PMID:21787760</ref>.
Mutations in SOS1 have been reported in Noonan syndrome and in type 1 hereditary gingival fibromatosis<ref>PMID:21787760</ref>.
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== Relevance ==
 
== Structural highlights ==
== Structural highlights ==
SOS1 domain structure contains histone domain (HD) residues 1-191, Dbl homology domain (DH) 203-389, pleckstrin homology domain (PH) 443-548, Ras exchange motif (REM) 601-648, catalytic domain 782-1020 and proline-rich region (PR) 1146-1297.
SOS1 domain structure contains histone domain (HD) residues 1-191, Dbl homology domain (DH) 203-389, pleckstrin homology domain (PH) 443-548, Ras exchange motif (REM) 601-648, catalytic domain 782-1020 and proline-rich region (PR) 1146-1297.
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</StructureSection>
 
==3D structures of son of sevenless==
==3D structures of son of sevenless==
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[[Son of sevenless 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*Son of sevenless 1; Domains - HD histone domain 1-191; DH Dbl homology 203-389; PH pleckstrin homology 443-548; REM+catalytic 601-1020
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**[[3ksy]] - hSOS1 - human<br />
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**[[1q9c]] - hSOS1 HD <br />
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**[[1awe]] - hSOS1 PH - NMR <br />
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**[[2ii0]] - hSOS1 REM+catalytic domains<br />
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**[[1dbh]] - hSOS1 DH+PH domains<br />
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**[[1xd4]], [[1xdv]] - hSOS1 DH+PH+REM+catalytic domains<br />
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**[[1pms]] - mSOS1 PH (mutant) - mouse - NMR <br />
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*Son of sevenless 1 complex
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**[[1bkd]] - hSOS1 REM+catalytic domains + HRas<br />
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**[[1xd2]] - hSOS1 REM+catalytic domains + HRas + GDP<br />
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*Son of sevenless 1 homolog
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**[[5ovd]] - hSOS1 REM+catalytic domains (mutant)<br />
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**[[6scm]], [[6sfr]], [[7avi]], [[7avl]], [[7avs]], [[7avt]], [[7avu]], [[7avv]], [[7avs]] - hSOS1 REM+catalytic domains + inhibitor<br />
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**[[5ove]], [[5ovg]], [[5ovf]] [[5ovi]], [[5ovh]] - hSOS1 REM+catalytic domains (mutant) + inhibitor<br />
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**[[1nvx]], [[1nvu]] - hSOS1 REM+catalytic domains + HRas + GTP<br />
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**[[1nvw]], [[1nvv]] - hSOS1 REM+catalytic domains + HRas + GNP<br />
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**[[4us0]], [[4us1]], [[4ury]], [[4urz]], [[4us2]], [[4urv]], [[4urw]], [[4urx]] - hSOS1 REM+catalytic domains + HRas + ligand<br />
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**[[5wfo]], [[5wfq]], [[5fwp]], [[5fwr]] - hSOS1 REM+catalytic domains + HRas + GNP + ligand<br />
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**[[6d5w]], [[6d5v]], [[6d5m]], [[6bvi]], [[6bvk]], [[6bvj]], [[6bvm]], [[6bvl]], [[6cuo]], [[6d5e]], [[6d59]], [[6d56]], [[6d55]], [[6d5h]], [[6d5g]], [[6d5j]], [[6d5l]], [[6cup]], [[6cur]], [[4nym]] - hSOS1 REM+catalytic domains + HRas + GNP + activator<br />
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**[[4nyi]], [[4nyj]], [[6v94]], [[6v9j]], [[6v9l]], [[6v9n]], [[6v9m]], [[6v9f]] - hSOS1 REM+catalytic domains + HRas + GNP + inhibitor<br />
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**[[6epl]] - hSOS1 REM+catalytic domains (mutant) + KRas<br />
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**[[7kfz]] - hSOS1 REM+catalytic domains + KRas + GNP – Cryo EM<br />
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**[[6epn]], [[6epm]], [[6epp]], [[6epo]] - hSOS1 REM+catalytic domains + KRas + inhibitor<br />
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*Son of sevenless 2
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**[[6eie]] - hSOS2 REM+catalytic domains (mutant)<br />
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}}
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== References ==
== References ==
<references/>
<references/>
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</StructureSection>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Human SOS1 REM+catalytic domains (olive) complex with HRas (green, blue), GTP, phosphate and Mg++ ion (green) (PDB code 1nvx)

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Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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