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7ul2
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 7ul2 is ON HOLD Authors: Robertson, M.J., Skiniotis, G. Description: CryoEM Structure of Inactive NTSR1 Bound to SR48692 and Nb6 [[Category: Unrele...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==CryoEM Structure of Inactive NTSR1 Bound to SR48692 and Nb6== | |
| - | + | <StructureSection load='7ul2' size='340' side='right'caption='[[7ul2]], [[Resolution|resolution]] 2.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7ul2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UL2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UL2 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=Q6Q:2-[[1-(7-chloranylquinolin-4-yl)-5-(2,6-dimethoxyphenyl)pyrazol-3-yl]carbonylamino]adamantane-2-carboxylic+acid'>Q6Q</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ul2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ul2 OCA], [https://pdbe.org/7ul2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ul2 RCSB], [https://www.ebi.ac.uk/pdbsum/7ul2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ul2 ProSAT]</span></td></tr> |
| - | [[Category: Robertson | + | </table> |
| - | [[Category: Skiniotis | + | == Function == |
| + | [https://www.uniprot.org/uniprot/OPRK_HUMAN OPRK_HUMAN] G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.<ref>PMID:12004055</ref> <ref>PMID:22437504</ref> <ref>PMID:7624359</ref> <ref>PMID:8060324</ref> [https://www.uniprot.org/uniprot/NTR1_HUMAN NTR1_HUMAN] Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Lama glama]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Robertson MJ]] | ||
| + | [[Category: Skiniotis G]] | ||
Current revision
CryoEM Structure of Inactive NTSR1 Bound to SR48692 and Nb6
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