7wlt

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==the Curved Structure of mPIEZO1 in Lipid Bilayer==
==the Curved Structure of mPIEZO1 in Lipid Bilayer==
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<StructureSection load='7wlt' size='340' side='right'caption='[[7wlt]]' scene=''>
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<StructureSection load='7wlt' size='340' side='right'caption='[[7wlt]], [[Resolution|resolution]] 3.46&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WLT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WLT FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7wlt]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WLT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WLT FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wlt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wlt OCA], [https://pdbe.org/7wlt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wlt RCSB], [https://www.ebi.ac.uk/pdbsum/7wlt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wlt ProSAT]</span></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=P5S:O-[(R)-{[(2R)-2,3-BIS(OCTADECANOYLOXY)PROPYL]OXY}(HYDROXY)PHOSPHORYL]-L-SERINE'>P5S</scene>, <scene name='pdbligand=PEE:1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE'>PEE</scene>, <scene name='pdbligand=PLX:(9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL'>PLX</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wlt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wlt OCA], [https://pdbe.org/7wlt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wlt RCSB], [https://www.ebi.ac.uk/pdbsum/7wlt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wlt ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/PIEZ1_MOUSE PIEZ1_MOUSE]] Pore-forming subunit of a mechanosensitive non-specific cation channel. Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling. In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation. Plays a key role in blood vessel formation and vascular structure in both development and adult physiology.<ref>PMID:20813920</ref> <ref>PMID:22343900</ref> <ref>PMID:24157948</ref> <ref>PMID:24958852</ref> <ref>PMID:25119035</ref>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Mus musculus]]
[[Category: Chen X]]
[[Category: Chen X]]
[[Category: Li S]]
[[Category: Li S]]
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[[Category: Li X]]
[[Category: Lin C]]
[[Category: Lin C]]
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[[Category: Xiao B]]
[[Category: Yang X]]
[[Category: Yang X]]

Current revision

the Curved Structure of mPIEZO1 in Lipid Bilayer

PDB ID 7wlt

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