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7xf8
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==Crystal Structure of Human Lysozyme Complexed with N-Acetyl-alpha-D-Glucosamine== | ==Crystal Structure of Human Lysozyme Complexed with N-Acetyl-alpha-D-Glucosamine== | ||
| - | <StructureSection load='7xf8' size='340' side='right'caption='[[7xf8]]' scene=''> | + | <StructureSection load='7xf8' size='340' side='right'caption='[[7xf8]], [[Resolution|resolution]] 1.60Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XF8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XF8 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7xf8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XF8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XF8 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xf8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xf8 OCA], [https://pdbe.org/7xf8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xf8 RCSB], [https://www.ebi.ac.uk/pdbsum/7xf8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xf8 ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xf8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xf8 OCA], [https://pdbe.org/7xf8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xf8 RCSB], [https://www.ebi.ac.uk/pdbsum/7xf8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xf8 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/LYSC_HUMAN LYSC_HUMAN] Defects in LYZ are a cause of amyloidosis type 8 (AMYL8) [MIM:[https://omim.org/entry/105200 105200]; also known as systemic non-neuropathic amyloidosis or Ostertag-type amyloidosis. AMYL8 is a hereditary generalized amyloidosis due to deposition of apolipoprotein A1, fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash.<ref>PMID:8464497</ref> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/LYSC_HUMAN LYSC_HUMAN] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Lysozyme 3D structures|Lysozyme 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Nam KH]] | [[Category: Nam KH]] | ||
Current revision
Crystal Structure of Human Lysozyme Complexed with N-Acetyl-alpha-D-Glucosamine
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