2ww7

From Proteopedia

(Difference between revisions)

Current revision

foldon containing beta-turn mimic

Structural highlights

2ww7 is a 6 chain structure with sequence from Escherichia virus T4. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.06Å
Ligands:	, , ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q76VI8_BPT2

Publication Abstract from PubMed

beta-Turns are secondary structure elements not only exposed on protein surfaces, but also frequently found to be buried in protein-protein interfaces. Protein engineering so far considered mainly the backbone-constraining properties of synthetic beta-turn mimics as parts of surface-exposed loops. A beta-turn mimic, Hot horizontal lineTap, that is available in gram amounts, provides two hydroxyl groups that enhance its turn-inducing properties besides being able to form side-chain-like interactions. NMR studies on cyclic hexapeptides harboring the Hot horizontal lineTap dipeptide proved its strong beta-turn-inducing capability. Crystallographic analyses of the trimeric fibritin-foldon/Hot horizontal lineTap hybrid reveal at atomic resolution how Hot horizontal lineTap replaces a betaI'-turn by a betaII'-type structure. Furthermore, Hot horizontal lineTap adapts to the complex protein environment by participating in several direct and water-bridged interactions across the foldon trimer interface. As building blocks, beta-turn mimics capable of both backbone and side-chain mimicry may simplify the design of synthetic proteins.

Structural characterization of a beta-turn mimic within a protein-protein interface.,Eckhardt B, Grosse W, Essen LO, Geyer A Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18336-41. Epub 2010 Oct 11. PMID:20937907^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Eckhardt B, Grosse W, Essen LO, Geyer A. Structural characterization of a beta-turn mimic within a protein-protein interface. Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18336-41. Epub 2010 Oct 11. PMID:20937907 doi:10.1073/pnas.1004187107

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2ww7"

@@ Line 3: / Line 3: @@
 <StructureSection load='2ww7' size='340' side='right'caption='[[2ww7]], [[Resolution|resolution]] 1.06&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2ww7]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WW7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WW7 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2ww7]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WW7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WW7 FirstGlance]. <br>
-</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=NA8:(1S)-1-CARBOXY-2-NAPHTHALEN-2-YLETHANAMINIUM'>NA8</scene>, <scene name='pdbligand=PRS:THIOPROLINE'>PRS</scene>, <scene name='pdbligand=TH6:4-HYDROXY-L-THREONINE'>TH6</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.06&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2ww6|2ww6]]</div></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=NA8:(1S)-1-CARBOXY-2-NAPHTHALEN-2-YLETHANAMINIUM'>NA8</scene>, <scene name='pdbligand=PRS:THIOPROLINE'>PRS</scene>, <scene name='pdbligand=TH6:4-HYDROXY-L-THREONINE'>TH6</scene></td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ww7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ww7 OCA], [https://pdbe.org/2ww7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ww7 RCSB], [https://www.ebi.ac.uk/pdbsum/2ww7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ww7 ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q76VI8_BPT2 Q76VI8_BPT2]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 24: / Line 26: @@
 __TOC__
 </StructureSection>
+[[Category: Escherichia virus T4]]
 [[Category: Large Structures]]
-[[Category: Eckhardt, B]]
+[[Category: Eckhardt B]]
-[[Category: Essen, L O]]
+[[Category: Essen L-O]]
-[[Category: Geyer, A]]
+[[Category: Geyer A]]
-[[Category: Grosse, W]]
+[[Category: Grosse W]]
-[[Category: Chaperone]]
-[[Category: D-amino acid]]
-[[Category: Viral protein]]

2ww7

From Proteopedia

Current revision

foldon containing beta-turn mimic

Structural highlights

Function

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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