This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
7unk
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 7unk is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures) |
|||
| (One intermediate revision not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Structure of Importin-4 bound to the H3-H4-ASF1 histone-histone chaperone complex== | |
| - | + | <StructureSection load='7unk' size='340' side='right'caption='[[7unk]], [[Resolution|resolution]] 3.45Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7unk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UNK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UNK FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7unk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7unk OCA], [https://pdbe.org/7unk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7unk RCSB], [https://www.ebi.ac.uk/pdbsum/7unk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7unk ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/H4_XENLA H4_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Saccharomyces cerevisiae]] | ||
| + | [[Category: Xenopus laevis]] | ||
| + | [[Category: Bernardes NE]] | ||
| + | [[Category: Chen Z]] | ||
| + | [[Category: Chook YM]] | ||
| + | [[Category: Fung HYJ]] | ||
| + | [[Category: Li Y]] | ||
Current revision
Structure of Importin-4 bound to the H3-H4-ASF1 histone-histone chaperone complex
| |||||||||||
