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7z9a

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'''Unreleased structure'''
 
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The entry 7z9a is ON HOLD until Paper Publication
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==Sam68==
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<StructureSection load='7z9a' size='340' side='right'caption='[[7z9a]], [[Resolution|resolution]] 2.57&Aring;' scene=''>
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Authors: Nadal, M., Fuentes-Prior, P.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7z9a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Z9A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Z9A FirstGlance]. <br>
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Description: Sam68
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.57&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=PGO:S-1,2-PROPANEDIOL'>PGO</scene></td></tr>
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[[Category: Fuentes-Prior, P]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7z9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7z9a OCA], [https://pdbe.org/7z9a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7z9a RCSB], [https://www.ebi.ac.uk/pdbsum/7z9a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7z9a ProSAT]</span></td></tr>
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[[Category: Nadal, M]]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KHDR1_HUMAN KHDR1_HUMAN] Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export.<ref>PMID:9013542</ref> <ref>PMID:9045636</ref> <ref>PMID:11585385</ref> <ref>PMID:1374686</ref> [UniProtKB:Q60749][UniProtKB:Q8UUW7] Isoform 3, which is expressed in growth-arrested cells only, inhibits S phase.<ref>PMID:9013542</ref> <ref>PMID:9045636</ref> <ref>PMID:11585385</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Fuentes-Prior P]]
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[[Category: Nadal M]]

Current revision

Sam68

PDB ID 7z9a

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