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7zl9

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'''Unreleased structure'''
 
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The entry 7zl9 is ON HOLD
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==Crystal structure of human GPCR Niacin receptor (HCA2)==
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<StructureSection load='7zl9' size='340' side='right'caption='[[7zl9]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7zl9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZL9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZL9 FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zl9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zl9 OCA], [https://pdbe.org/7zl9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zl9 RCSB], [https://www.ebi.ac.uk/pdbsum/7zl9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zl9 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.[https://www.uniprot.org/uniprot/HCAR2_HUMAN HCAR2_HUMAN] Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.<ref>PMID:17932499</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Escherichia coli]]
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: FiBerto JF]]
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[[Category: Gao RG]]
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[[Category: Han GW]]
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[[Category: Kang HJ]]
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[[Category: Kenakin T]]
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[[Category: Li XM]]
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[[Category: Liu ZJ]]
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[[Category: Peng W]]
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[[Category: Pileski R]]
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[[Category: Qu L]]
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[[Category: Rao ZH]]
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[[Category: Roth BL]]
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[[Category: Stevens RC]]
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[[Category: Tong JH]]
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[[Category: Wang JJ]]
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[[Category: Wang Q]]
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[[Category: Wu LJ]]
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[[Category: Wu YR]]
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[[Category: Yang Y]]
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[[Category: Zhang XC]]
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[[Category: Zhao SW]]

Current revision

Crystal structure of human GPCR Niacin receptor (HCA2)

PDB ID 7zl9

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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