6i8c

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:49, 7 February 2024) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
-
==Crystal structure of the murine beta-2-microglobulin==
+
==Crystal structure of the murine beta-2-microglobulin.==
<StructureSection load='6i8c' size='340' side='right'caption='[[6i8c]], [[Resolution|resolution]] 1.92&Aring;' scene=''>
<StructureSection load='6i8c' size='340' side='right'caption='[[6i8c]], [[Resolution|resolution]] 1.92&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[6i8c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I8C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6I8C FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[6i8c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I8C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6I8C FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.92&#8491;</td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">B2m ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6i8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i8c OCA], [https://pdbe.org/6i8c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6i8c RCSB], [https://www.ebi.ac.uk/pdbsum/6i8c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6i8c ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6i8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i8c OCA], [https://pdbe.org/6i8c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6i8c RCSB], [https://www.ebi.ac.uk/pdbsum/6i8c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6i8c ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[https://www.uniprot.org/uniprot/B2MG_MOUSE B2MG_MOUSE]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
+
[https://www.uniprot.org/uniprot/B2MG_MOUSE B2MG_MOUSE] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
-
<div style="background-color:#fffaf0;">
+
-
== Publication Abstract from PubMed ==
+
-
The molecular bases of amyloid aggregation propensity are still poorly understood, especially for proteins that display a stable folded native structure. A prototypic example is human beta-2 microglobulin (beta2m), which, when accumulated in patients, gives rise to dialysis-related amyloidosis. Interestingly, although the physiologic concentration of beta2m in mice is five times higher than that found in human patients, no amyloid deposits are observed in mice. Moreover, murine beta2m (mbeta2m) not only displays a lower amyloid propensity both in vivo and in vitro but also inhibits the aggregation of human beta2m in vitro. Here, we compared human and mbeta2m for their aggregation propensity, ability to form soluble oligomers, stability, three-dimensional structure and dynamics. Our results indicate that mbeta2m low-aggregation propensity is due to two concomitant aspects: the low-aggregation propensity of its primary sequence combined with the absence of high-energy amyloid-competent conformations under native conditions. The identification of the specific properties determining the low-aggregation propensity of mouse beta2m will help delineate the molecular risk factors which cause a folded protein to aggregate.
+
-
 
+
-
Biochemical and biophysical comparison of human and mouse beta-2 microglobulin reveals the molecular determinants of low amyloid propensity.,Achour A, Broggini L, Han X, Sun R, Santambrogio C, Buratto J, Visentin C, Barbiroli A, De Luca CMG, Sormanni P, Moda F, De Simone A, Sandalova T, Grandori R, Camilloni C, Ricagno S FEBS J. 2019 Aug 17. doi: 10.1111/febs.15046. PMID:31420997<ref>PMID:31420997</ref>
+
-
 
+
-
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+
-
</div>
+
-
<div class="pdbe-citations 6i8c" style="background-color:#fffaf0;"></div>
+
==See Also==
==See Also==
*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
-
== References ==
 
-
<references/>
 
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Lk3 transgenic mice]]
+
[[Category: Mus musculus]]
-
[[Category: Achour, A]]
+
[[Category: Achour A]]
-
[[Category: Ricagno, S]]
+
[[Category: Ricagno S]]
-
[[Category: Sandalova, T]]
+
[[Category: Sandalova T]]
-
[[Category: Sun, R]]
+
[[Category: Sun R]]
-
[[Category: Beta-2-microglobulin]]
+
-
[[Category: Immune system]]
+
-
[[Category: Mhc class i]]
+
-
[[Category: Protein aggregation]]
+

Current revision

Crystal structure of the murine beta-2-microglobulin.

PDB ID 6i8c

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6i8c"
Personal tools