3iez

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Current revision (10:05, 21 February 2024) (edit) (undo)
 
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<StructureSection load='3iez' size='340' side='right'caption='[[3iez]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
<StructureSection load='3iez' size='340' side='right'caption='[[3iez]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3iez]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IEZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IEZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3iez]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IEZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IEZ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IQGAP2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3iez FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iez OCA], [https://pdbe.org/3iez PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3iez RCSB], [https://www.ebi.ac.uk/pdbsum/3iez PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3iez ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3iez FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iez OCA], [https://pdbe.org/3iez PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3iez RCSB], [https://www.ebi.ac.uk/pdbsum/3iez PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3iez ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/IQGA2_HUMAN IQGA2_HUMAN]] Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin.
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[https://www.uniprot.org/uniprot/IQGA2_HUMAN IQGA2_HUMAN] Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Arrowsmith, C H]]
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[[Category: Arrowsmith CH]]
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[[Category: Bochkarev, A]]
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[[Category: Bochkarev A]]
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[[Category: Bountra, C]]
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[[Category: Bountra C]]
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[[Category: Crombet, L]]
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[[Category: Crombet L]]
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[[Category: Edwards, A M]]
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[[Category: Edwards AM]]
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[[Category: Nedyalkova, L]]
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[[Category: Nedyalkova L]]
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[[Category: Park, H]]
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[[Category: Park H]]
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[[Category: Structural genomic]]
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[[Category: Tempel W]]
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[[Category: Tempel, W]]
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[[Category: Tong Y]]
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[[Category: Tong, Y]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J]]
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[[Category: Zhong N]]
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[[Category: Zhong, N]]
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[[Category: Calmodulin-binding]]
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[[Category: Gap]]
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[[Category: Phosphoprotein]]
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[[Category: Sgc]]
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[[Category: Signaling protein]]
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Current revision

Crystal structure of the RasGAP C-terminal (RGC) domain of IQGAP2

PDB ID 3iez

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