3ii2

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<StructureSection load='3ii2' size='340' side='right'caption='[[3ii2]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='3ii2' size='340' side='right'caption='[[3ii2]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3ii2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Afv-1 Afv-1]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2oq8 2oq8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3II2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3II2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3ii2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Acidianus_filamentous_virus_1 Acidianus filamentous virus 1]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2oq8 2oq8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3II2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3II2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3ii3|3ii3]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AFV1 orf157 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=235266 AFV-1])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ii2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ii2 OCA], [https://pdbe.org/3ii2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ii2 RCSB], [https://www.ebi.ac.uk/pdbsum/3ii2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ii2 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ii2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ii2 OCA], [https://pdbe.org/3ii2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ii2 RCSB], [https://www.ebi.ac.uk/pdbsum/3ii2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ii2 ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Y157_AFV1Y Y157_AFV1Y]
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Acidianus filamentous virus 1 (AFV1) (Lipothrixviridae) is an enveloped filamentous virus that was characterized from a crenarchaeal host. It infects Acidianus species that thrive in the acidic hot springs (&gt;85 degrees C and pH &lt;3) of Yellowstone National Park, WY. The AFV1 20.8-kb, linear, double-stranded DNA genome encodes 40 putative open reading frames whose sequences generally show little similarity to other genes in the sequence databases. Because three-dimensional structures are more conserved than sequences and hence are more effective at revealing function, we set out to determine protein structures from putative AFV1 open reading frames (ORF). The crystal structure of ORF157 reveals an alpha+beta protein with a novel fold that remotely resembles the nucleotidyltransferase topology. In vitro, AFV1-157 displays a nuclease activity on linear double-stranded DNA. Alanine substitution mutations demonstrated that E86 is essential to catalysis. AFV1-157 represents a novel class of nuclease, but its exact role in vivo remains to be determined.
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ORF157 from the archaeal virus Acidianus filamentous virus 1 defines a new class of nuclease.,Goulet A, Pina M, Redder P, Prangishvili D, Vera L, Lichiere J, Leulliot N, van Tilbeurgh H, Ortiz-Lombardia M, Campanacci V, Cambillau C J Virol. 2010 May;84(10):5025-31. Epub 2010 Mar 3. PMID:20200253<ref>PMID:20200253</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3ii2" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Afv-1]]
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[[Category: Acidianus filamentous virus 1]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Cambillau, C]]
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[[Category: Cambillau C]]
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[[Category: Campanacci, V]]
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[[Category: Campanacci V]]
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[[Category: Goulet, A]]
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[[Category: Goulet A]]
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[[Category: Porciero, S]]
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[[Category: Porciero S]]
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[[Category: Prangishvili, D]]
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[[Category: Prangishvili D]]
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[[Category: Tilbeurgh, H van]]
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[[Category: Van Tilbeurgh H]]
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[[Category: Archaea]]
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[[Category: Dna binding protein]]
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[[Category: Nuclease]]
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[[Category: Virus]]
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Current revision

Structure of ORF157 from Acidianus Filamentous Virus 1

PDB ID 3ii2

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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