3iz3

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3iz3]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Bombyx_mori_cypovirus_1 Bombyx mori cypovirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IZ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IZ3 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3iz3]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Bombyx_mori_cypovirus_1 Bombyx mori cypovirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IZ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IZ3 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3iz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iz3 OCA], [https://pdbe.org/3iz3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3iz3 RCSB], [https://www.ebi.ac.uk/pdbsum/3iz3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3iz3 ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3iz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iz3 OCA], [https://pdbe.org/3iz3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3iz3 RCSB], [https://www.ebi.ac.uk/pdbsum/3iz3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3iz3 ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q914N6_CPVBM Q914N6_CPVBM]
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The cytoplasmic polyhedrosis virus (CPV) from the family Reoviridae belongs to a subgroup of "turreted" reoviruses, in which the mRNA capping activity occurs in a pentameric turret. We report a full atomic model of CPV built from a 3D density map obtained using cryoelectron microscopy. The image data for the 3D reconstruction were acquired exclusively from a CCD camera. Our structure shows that the enzymatic domains of the pentameric turret of CPV are topologically conserved and that there are five unique channels connecting the guanylyltransferase and methyltransferase regions. This structural organization reveals how the channels guide nascent mRNA sequentially to guanylyltransferase, 7-N-methyltransferase, and 2'-O-methyltransferase in the turret, undergoing the highly coordinated mRNA capping activity. Furthermore, by fitting the deduced amino acid sequence of the protein VP5 to 120 large protrusion proteins on the CPV capsid shell, we confirmed that this protrusion protein is encoded by CPV RNA segment 7.
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Atomic model of a cypovirus built from cryo-EM structure provides insight into the mechanism of mRNA capping.,Cheng L, Sun J, Zhang K, Mou Z, Huang X, Ji G, Sun F, Zhang J, Zhu P Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1373-8. Epub 2011 Jan 10. PMID:21220303<ref>PMID:21220303</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3iz3" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
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== References ==
 
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<references/>
 
__TOC__
__TOC__
</SX>
</SX>
[[Category: Bombyx mori cypovirus 1]]
[[Category: Bombyx mori cypovirus 1]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Cheng, L]]
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[[Category: Cheng L]]
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[[Category: Huang, X]]
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[[Category: Huang X]]
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[[Category: Ji, G]]
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[[Category: Ji G]]
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[[Category: Mou, Z]]
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[[Category: Mou Z]]
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[[Category: Sun, F]]
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[[Category: Sun F]]
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[[Category: Sun, J]]
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[[Category: Sun J]]
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[[Category: Zhang, J]]
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[[Category: Zhang J]]
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[[Category: Zhang, K]]
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[[Category: Zhang K]]
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[[Category: Zhu, P]]
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[[Category: Zhu P]]
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[[Category: Cryoelectron microscopy]]
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[[Category: Cytoplasmic polyhedrosis virus]]
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[[Category: Icosahedral virus]]
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[[Category: Reovirus]]
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[[Category: Transcription]]
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[[Category: Virus]]
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Current revision

CryoEM structure of cytoplasmic polyhedrosis virus

3iz3, resolution 3.90Å

Proteopedia Page Contributors and Editors (what is this?)

OCA

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