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3j07

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==Model of a 24mer alphaB-crystallin multimer==
==Model of a 24mer alphaB-crystallin multimer==
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<SX load='3j07' size='340' side='right' viewer='molstar' caption='[[3j07]], [[Resolution|resolution]] 20.00&Aring;, [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
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<SX load='3j07' size='340' side='right' viewer='molstar' caption='[[3j07]], [[Resolution|resolution]] 20.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3j07]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J07 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J07 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3j07]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J07 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J07 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2klr|2klr]]</div></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy , Hybrid , Solid-state NMR , X-ray solution scattering, [[Resolution|Resolution]] 20&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CRYAB, CRYA2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j07 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j07 OCA], [https://pdbe.org/3j07 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j07 RCSB], [https://www.ebi.ac.uk/pdbsum/3j07 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j07 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j07 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j07 OCA], [https://pdbe.org/3j07 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j07 RCSB], [https://www.ebi.ac.uk/pdbsum/3j07 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j07 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[https://www.uniprot.org/uniprot/CRYAB_HUMAN CRYAB_HUMAN]] Posterior polar cataract;Alpha-crystallinopathy;Zonular cataract;Familial isolated dilated cardiomyopathy;Fatal infantile hypertonic myofibrillar myopathy. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/CRYAB_HUMAN CRYAB_HUMAN] Posterior polar cataract;Alpha-crystallinopathy;Zonular cataract;Familial isolated dilated cardiomyopathy;Fatal infantile hypertonic myofibrillar myopathy. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/CRYAB_HUMAN CRYAB_HUMAN]] May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.
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[https://www.uniprot.org/uniprot/CRYAB_HUMAN CRYAB_HUMAN] May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Alpha-crystallins are molecular chaperones that protect vertebrate eye lens proteins from detrimental protein aggregation. alphaB-Crystallin, 1 of the 2 alpha-crystallin isoforms, is also associated with myopathies and neuropathological diseases. Despite the importance of alpha-crystallins in protein homeostasis, only little is known about their quaternary structures because of their seemingly polydisperse nature. Here, we analyzed the structures of recombinant alpha-crystallins using biophysical methods. In contrast to previous reports, we show that alphaB-crystallin assembles into defined oligomers consisting of 24 subunits. The 3-dimensional (3D) reconstruction of alphaB-crystallin by electron microscopy reveals a sphere-like structure with large openings to the interior of the protein. alphaA-Crystallin forms, in addition to complexes of 24 subunits, also smaller oligomers and large clusters consisting of individual oligomers. This propensity might explain the previously reported polydisperse nature of alpha-crystallin.
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The eye lens chaperone alpha-crystallin forms defined globular assemblies.,Peschek J, Braun N, Franzmann TM, Georgalis Y, Haslbeck M, Weinkauf S, Buchner J Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13272-7. doi:, 10.1073/pnas.0902651106. Epub 2009 Jul 27. PMID:19651604<ref>PMID:19651604</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3j07" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
*[[Crystallin 3D structures|Crystallin 3D structures]]
*[[Crystallin 3D structures|Crystallin 3D structures]]
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== References ==
 
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<references/>
 
__TOC__
__TOC__
</SX>
</SX>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bardiaux, B]]
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[[Category: Bardiaux B]]
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[[Category: Dove, K K]]
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[[Category: Dove KK]]
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[[Category: Gonen, T]]
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[[Category: Gonen T]]
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[[Category: Jehle, S]]
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[[Category: Jehle S]]
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[[Category: Klevit, R E]]
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[[Category: Klevit RE]]
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[[Category: Oschkinat, H]]
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[[Category: Oschkinat H]]
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[[Category: Rajagopal, P]]
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[[Category: Rajagopal P]]
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[[Category: Vollmar, B]]
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[[Category: Vollmar B]]
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[[Category: Chaperone]]
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[[Category: Shsp]]
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Current revision

Model of a 24mer alphaB-crystallin multimer

3j07, resolution 20.00Å

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