3j1t
From Proteopedia
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<SX load='3j1t' size='340' side='right' viewer='molstar' caption='[[3j1t]], [[Resolution|resolution]] 9.70Å' scene=''> | <SX load='3j1t' size='340' side='right' viewer='molstar' caption='[[3j1t]], [[Resolution|resolution]] 9.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3j1t]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3j1t]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. The August 2014 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Dynein'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2014_8 10.2210/rcsb_pdb/mom_2014_8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J1T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J1T FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 9.7Å</td></tr> |
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j1t OCA], [https://pdbe.org/3j1t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j1t RCSB], [https://www.ebi.ac.uk/pdbsum/3j1t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j1t ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j1t OCA], [https://pdbe.org/3j1t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j1t RCSB], [https://www.ebi.ac.uk/pdbsum/3j1t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j1t ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | + | [https://www.uniprot.org/uniprot/DYHC1_MOUSE DYHC1_MOUSE] Defects in Dync1h1 are the cause of the 'Legs at odd angles' (LOA) phenotype, an autosomal dominant trait where affected animals display unusual twisting of the body and clenching of the hindlimbs when suspended by the tail. Heterozygotes suffer age-related progressive loss of muscle tone and locomotor ability without major reduction in life-span while homozygotes show a more severe phenotype with an inability to move or feed, and die within 24 hours of birth. LOA mutants display defects in migration of facial motor neuron cell bodies and impaired retrograde transport in spinal cord motor neurons. Defects in Dync1h1 are the cause of the Cramping 1 (Cra1) phenotype, an autosomal dominant trait where affected animals display unusual twisting of the body and clenching of the hindlimbs when suspended by the tail. Heterozygotes suffer age-related progressive loss of muscle tone and locomotor ability without major reduction in life-span while homozygotes show a more severe phenotype with an inability to move or feed, and die within 24 hours of birth. | |
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/DYHC1_MOUSE DYHC1_MOUSE] Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. | |
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==See Also== | ==See Also== | ||
*[[Dynein 3D structures|Dynein 3D structures]] | *[[Dynein 3D structures|Dynein 3D structures]] | ||
*[[Tubulin 3D Structures|Tubulin 3D Structures]] | *[[Tubulin 3D Structures|Tubulin 3D Structures]] | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</SX> | </SX> | ||
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[[Category: Dynein]] | [[Category: Dynein]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Mus musculus]] |
[[Category: RCSB PDB Molecule of the Month]] | [[Category: RCSB PDB Molecule of the Month]] | ||
| - | [[Category: Hernandez-Lopez | + | [[Category: Hernandez-Lopez R]] |
| - | [[Category: Huang | + | [[Category: Huang J]] |
| - | [[Category: Leschziner | + | [[Category: Leschziner AE]] |
| - | [[Category: Reck-Peterson | + | [[Category: Reck-Peterson SL]] |
| - | [[Category: Redwine | + | [[Category: Redwine WB]] |
| - | [[Category: Zou | + | [[Category: Zou S]] |
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Current revision
High affinity dynein microtubule binding domain - tubulin complex
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