7xk9
From Proteopedia
(Difference between revisions)
m (Protected "7xk9" [edit=sysop:move=sysop]) |
|||
| (2 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Structure of human beta2 adrenergic receptor bound to constrained isoproterenol== | |
| - | + | <StructureSection load='7xk9' size='340' side='right'caption='[[7xk9]], [[Resolution|resolution]] 3.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7xk9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XK9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XK9 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GJ6:(5R,6R)-6-(propan-2-ylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol'>GJ6</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xk9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xk9 OCA], [https://pdbe.org/7xk9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xk9 RCSB], [https://www.ebi.ac.uk/pdbsum/7xk9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xk9 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Clark | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/ADRB2_HUMAN ADRB2_HUMAN] Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.[https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: Kaindl | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: Liu | + | [[Category: Escherichia virus T4]] |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Sunahara | + | [[Category: Clark M]] |
| - | [[Category: | + | [[Category: Dror R]] |
| - | [[Category: | + | [[Category: Gmeiner P]] |
| + | [[Category: Hubner H]] | ||
| + | [[Category: Kaindl J]] | ||
| + | [[Category: Kobilka BK]] | ||
| + | [[Category: Liu X]] | ||
| + | [[Category: Maul L]] | ||
| + | [[Category: Mayer D]] | ||
| + | [[Category: Shonberg J]] | ||
| + | [[Category: Stobel A]] | ||
| + | [[Category: Sunahara R]] | ||
| + | [[Category: Venkatakrishnan A]] | ||
| + | [[Category: Xu X]] | ||
Current revision
Structure of human beta2 adrenergic receptor bound to constrained isoproterenol
| |||||||||||
Categories: Escherichia virus T4 | Homo sapiens | Large Structures | Clark M | Dror R | Gmeiner P | Hubner H | Kaindl J | Kobilka BK | Liu X | Maul L | Mayer D | Shonberg J | Stobel A | Sunahara R | Venkatakrishnan A | Xu X
