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2xvs

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Current revision (14:00, 1 February 2024) (edit) (undo)
 
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<StructureSection load='2xvs' size='340' side='right'caption='[[2xvs]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='2xvs' size='340' side='right'caption='[[2xvs]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2xvs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XVS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XVS FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2xvs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XVS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XVS FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xvs OCA], [https://pdbe.org/2xvs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xvs RCSB], [https://www.ebi.ac.uk/pdbsum/2xvs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xvs ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xvs OCA], [https://pdbe.org/2xvs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xvs RCSB], [https://www.ebi.ac.uk/pdbsum/2xvs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xvs ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/TTC5_HUMAN TTC5_HUMAN]] Adapter protein involved in p53/TP53 response that acts by regulating and mediating the assembly of multi-protein complexes. Required to facilitate the interaction between JMY and p300/EP300 and increase p53/TP53-dependent transcription and apoptosis. Prevents p53/TP53 degradation by MDM2 (By similarity).
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[https://www.uniprot.org/uniprot/TTC5_HUMAN TTC5_HUMAN] Adapter protein involved in p53/TP53 response that acts by regulating and mediating the assembly of multi-protein complexes. Required to facilitate the interaction between JMY and p300/EP300 and increase p53/TP53-dependent transcription and apoptosis. Prevents p53/TP53 degradation by MDM2 (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Adams, J]]
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[[Category: Adams J]]
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[[Category: Bullock, A N]]
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[[Category: Bullock AN]]
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[[Category: Coutts, A S]]
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[[Category: Coutts AS]]
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[[Category: Knapp, S]]
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[[Category: Knapp S]]
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[[Category: Maniam, S]]
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[[Category: La Thangue B]]
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[[Category: Pike, A C.W]]
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[[Category: Maniam S]]
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[[Category: Sharpe, T D]]
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[[Category: Pike ACW]]
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[[Category: Thangue, B La]]
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[[Category: Sharpe TD]]
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[[Category: Antitumor protein]]
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[[Category: P300]]
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[[Category: P53 cofactor]]
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[[Category: Stress-response]]
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Current revision

Crystal structure of human TTC5 (Strap) C-terminal OB domain

PDB ID 2xvs

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