2ygc
From Proteopedia
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<StructureSection load='2ygc' size='340' side='right'caption='[[2ygc]], [[Resolution|resolution]] 3.02Å' scene=''> | <StructureSection load='2ygc' size='340' side='right'caption='[[2ygc]], [[Resolution|resolution]] 3.02Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2ygc]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2ygc]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Vaccinia_virus_Western_Reserve Vaccinia virus Western Reserve]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YGC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YGC FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.02Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ygc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ygc OCA], [https://pdbe.org/2ygc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ygc RCSB], [https://www.ebi.ac.uk/pdbsum/2ygc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ygc ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ygc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ygc OCA], [https://pdbe.org/2ygc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ygc RCSB], [https://www.ebi.ac.uk/pdbsum/2ygc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ygc ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == Function == | ||
| - | [[https://www.uniprot.org/uniprot/D13_VACCW D13_VACCW]] Scaffold protein which forms a transitory spherical honeycomb lattice providing curvature and rigidity to the convex membrane of crescent and immature virions (IV). This association occurs concomitantly with viral membrane formation. Targeted by the drug rifampicin, which prevents the formation of this lattice, and hence virus morphogenesis. In the presence of rifampicin, irregularly shaped membranes that lack the honeycomb layer accumulate around areas of electron-dense viroplasm. This layer is lost from virions during maturation from IV to mature virion (MV), through the proteolysis of A17 N-terminus. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Vaccinia virus | + | [[Category: Vaccinia virus Western Reserve]] |
| - | [[Category: Bahar | + | [[Category: Bahar MW]] |
| - | [[Category: Graham | + | [[Category: Graham SC]] |
| - | [[Category: Grimes | + | [[Category: Grimes JM]] |
| - | [[Category: Stuart | + | [[Category: Stuart DI]] |
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Current revision
Structure of vaccinia virus D13 scaffolding protein
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