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1eqt

From Proteopedia

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[[Image:1eqt.gif|left|200px]]<br />
 
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<applet load="1eqt" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1eqt, resolution 1.60&Aring;" />
 
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'''MET-RANTES'''<br />
 
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==Disease==
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==MET-RANTES==
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Known diseases associated with this structure: HIV-1 disease, delayed progression of OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=187011 187011]], HIV-1 disease, rapid progression of OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=187011 187011]]
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<StructureSection load='1eqt' size='340' side='right'caption='[[1eqt]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1eqt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EQT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EQT FirstGlance]. <br>
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1EQT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1EQT OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1eqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1eqt OCA], [https://pdbe.org/1eqt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1eqt RCSB], [https://www.ebi.ac.uk/pdbsum/1eqt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1eqt ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CCL5_HUMAN CCL5_HUMAN] Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. Binds to CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils.<ref>PMID:16791620</ref> <ref>PMID:1380064</ref> <ref>PMID:8525373</ref> <ref>PMID:9516414</ref> <ref>PMID:15923218</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eq/1eqt_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1eqt ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Gryczynski, Z.]]
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[[Category: Gryczynski Z]]
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[[Category: Hoover, D.M.]]
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[[Category: Hoover DM]]
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[[Category: Proudfoot, A.E.I.]]
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[[Category: Proudfoot AEI]]
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[[Category: Shaw, J.]]
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[[Category: Shaw J]]
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[[Category: Wells, T.]]
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[[Category: Wells T]]
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[[Category: SO4]]
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[[Category: chemoattractant]]
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[[Category: cytokine]]
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[[Category: rantes]]
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[[Category: x-ray structure]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 16:45:43 2007''
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Current revision

MET-RANTES

PDB ID 1eqt

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