7o6r
From Proteopedia
(Difference between revisions)
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==Crystal structure of bovine Hsc70(aa1-554)E213A/D214A in complex with 1H-Indazole== | ==Crystal structure of bovine Hsc70(aa1-554)E213A/D214A in complex with 1H-Indazole== | ||
| - | <StructureSection load='7o6r' size='340' side='right'caption='[[7o6r]]' scene=''> | + | <StructureSection load='7o6r' size='340' side='right'caption='[[7o6r]], [[Resolution|resolution]] 2.00Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7O6R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7O6R FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7o6r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7O6R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7O6R FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7o6r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7o6r OCA], [https://pdbe.org/7o6r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7o6r RCSB], [https://www.ebi.ac.uk/pdbsum/7o6r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7o6r ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=LZ1:1H-INDAZOLE'>LZ1</scene>, <scene name='pdbligand=TMO:TRIMETHYLAMINE+OXIDE'>TMO</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7o6r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7o6r OCA], [https://pdbe.org/7o6r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7o6r RCSB], [https://www.ebi.ac.uk/pdbsum/7o6r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7o6r ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/HSP7C_BOVIN HSP7C_BOVIN] Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex (By similarity). | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Bos taurus]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Grimm C]] | [[Category: Grimm C]] | ||
[[Category: Sotriffer C]] | [[Category: Sotriffer C]] | ||
[[Category: Zehe M]] | [[Category: Zehe M]] | ||
Current revision
Crystal structure of bovine Hsc70(aa1-554)E213A/D214A in complex with 1H-Indazole
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