7q4l
From Proteopedia
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| - | ==== | + | ==The solution structure of hsDND1 RRM12 bound to CUUAUUUG RNA== |
<StructureSection load='7q4l' size='340' side='right'caption='[[7q4l]]' scene=''> | <StructureSection load='7q4l' size='340' side='right'caption='[[7q4l]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full | + | <table><tr><td colspan='2'>[[7q4l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q4L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q4L FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q4l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q4l OCA], [https://pdbe.org/7q4l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q4l RCSB], [https://www.ebi.ac.uk/pdbsum/7q4l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q4l ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q4l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q4l OCA], [https://pdbe.org/7q4l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q4l RCSB], [https://www.ebi.ac.uk/pdbsum/7q4l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q4l ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DND1_HUMAN DND1_HUMAN] RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells (By similarity). Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs. Sequence-specific RNA-binding factor that binds specifically to U-rich regions (URRs) in the 3' untranslated region (3'-UTR) of several mRNAs. Does not bind to miRNAs. May play a role during primordial germ cell (PGC) survival (By similarity). However, does not seem to be essential for PGC migration (By similarity).<ref>PMID:18155131</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Allain FHT]] |
| + | [[Category: Duszczyk MM]] | ||
Current revision
The solution structure of hsDND1 RRM12 bound to CUUAUUUG RNA
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