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1esl

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(New page: 200px<br /> <applet load="1esl" size="450" color="white" frame="true" align="right" spinBox="true" caption="1esl, resolution 2.0&Aring;" /> '''INSIGHT INTO E-SELEC...)
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[[Image:1esl.gif|left|200px]]<br />
 
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<applet load="1esl" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1esl, resolution 2.0&Aring;" />
 
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'''INSIGHT INTO E-SELECTIN(SLASH)LIGAND INTERACTION FROM THE CRYSTAL STRUCTURE AND MUTAGENESIS OF THE LEC(SLASH)EGF DOMAINS'''<br />
 
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==Overview==
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==INSIGHT INTO E-SELECTIN(SLASH)LIGAND INTERACTION FROM THE CRYSTAL STRUCTURE AND MUTAGENESIS OF THE LEC(SLASH)EGF DOMAINS==
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The three-dimensional structure of the ligand-binding region of human, E-selectin has been determined at 2.0 A resolution. The structure reveals, limited contact between the two domains and a coordination of Ca2+ not, predicted from other C-type lectins. Structure/function analysis indicates, a defined region and specific amino-acid side chains that may be involved, in ligand binding. These features of the E-selectin/ligand interaction, have important implications for understanding the recruitment of, leukocytes to sites of inflammation.
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<StructureSection load='1esl' size='340' side='right'caption='[[1esl]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1esl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ESL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ESL FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1esl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1esl OCA], [https://pdbe.org/1esl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1esl RCSB], [https://www.ebi.ac.uk/pdbsum/1esl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1esl ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LYAM2_HUMAN LYAM2_HUMAN] Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis.<ref>PMID:1689848</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/es/1esl_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1esl ConSurf].
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<div style="clear:both"></div>
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==Disease==
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==See Also==
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Known diseases associated with this structure: Atherosclerosis, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=131210 131210]], Blood pressure regulation QTL OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=131210 131210]], IgA nephropathy, susceptiblity to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=131210 131210]]
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*[[Selectin|Selectin]]
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== References ==
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==About this Structure==
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<references/>
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1ESL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CA and CL as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1ESL OCA].
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__TOC__
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</StructureSection>
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==Reference==
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Insight into E-selectin/ligand interaction from the crystal structure and mutagenesis of the lec/EGF domains., Graves BJ, Crowther RL, Chandran C, Rumberger JM, Li S, Huang KS, Presky DH, Familletti PC, Wolitzky BA, Burns DK, Nature. 1994 Feb 10;367(6463):532-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7509040 7509040]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Crowther, R.L.]]
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[[Category: Crowther RL]]
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[[Category: Graves, B.J.]]
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[[Category: Graves BJ]]
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[[Category: CA]]
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[[Category: CL]]
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[[Category: cell adhesion protein]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 16:46:22 2007''
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Current revision

INSIGHT INTO E-SELECTIN(SLASH)LIGAND INTERACTION FROM THE CRYSTAL STRUCTURE AND MUTAGENESIS OF THE LEC(SLASH)EGF DOMAINS

PDB ID 1esl

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