1et1

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(New page: 200px<br /> <applet load="1et1" size="450" color="white" frame="true" align="right" spinBox="true" caption="1et1, resolution 0.90&Aring;" /> '''CRYSTAL STRUCTURE O...)
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[[Image:1et1.gif|left|200px]]<br />
 
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<applet load="1et1" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1et1, resolution 0.90&Aring;" />
 
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'''CRYSTAL STRUCTURE OF HUMAN PARATHYROID HORMONE 1-34 AT 0.9 A RESOLUTION'''<br />
 
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==Overview==
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==CRYSTAL STRUCTURE OF HUMAN PARATHYROID HORMONE 1-34 AT 0.9 A RESOLUTION==
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The N-terminal fragment 1-34 of parathyroid hormone (PTH), administered, intermittently, results in increased bone formation in patients with, osteoporosis. PTH and a related molecule, parathyroid hormone-related, peptide (PTHrP), act on cells via a common PTH/PTHrP receptor. To define, more precisely the ligand-receptor interactions, we have crystallized, human PTH (hPTH)-(1-34) and determined the structure to 0.9-A resolution., hPTH-(1-34) crystallizes as a slightly bent, long helical dimer. Analysis, reveals that the extended helical conformation of hPTH-(1-34) is the, likely bioactive conformation. We have developed molecular models for the, interaction of hPTH-(1-34) and hPTHrP-(1-34) with the PTH/PTHrP receptor., A receptor binding pocket for the N terminus of hPTH-(1-34) and a, hydrophobic interface with the receptor for the C terminus of hPTH-(1-34), are proposed.
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<StructureSection load='1et1' size='340' side='right'caption='[[1et1]], [[Resolution|resolution]] 0.90&Aring;' scene=''>
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== Structural highlights ==
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==Disease==
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<table><tr><td colspan='2'>[[1et1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ET1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ET1 FirstGlance]. <br>
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Known diseases associated with this structure: Hypoparathyroidism, autosomal dominant OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=168450 168450]], Hypoparathyroidism, autosomal recessive OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=168450 168450]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1et1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1et1 OCA], [https://pdbe.org/1et1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1et1 RCSB], [https://www.ebi.ac.uk/pdbsum/1et1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1et1 ProSAT]</span></td></tr>
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1ET1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1ET1 OCA].
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</table>
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== Disease ==
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==Reference==
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[https://www.uniprot.org/uniprot/PTHY_HUMAN PTHY_HUMAN] Defects in PTH are a cause of familial isolated hypoparathyroidism (FIH) [MIM:[https://omim.org/entry/146200 146200]; also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.<ref>PMID:2212001</ref> <ref>PMID:10523031</ref> <ref>PMID:18056632</ref>
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Crystal structure of human parathyroid hormone 1-34 at 0.9-A resolution., Jin L, Briggs SL, Chandrasekhar S, Chirgadze NY, Clawson DK, Schevitz RW, Smiley DL, Tashjian AH, Zhang F, J Biol Chem. 2000 Sep 1;275(35):27238-44. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10837469 10837469]
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== Function ==
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[https://www.uniprot.org/uniprot/PTHY_HUMAN PTHY_HUMAN] PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells.<ref>PMID:21076856</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/et/1et1_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1et1 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Briggs, S.L.]]
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[[Category: Briggs SL]]
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[[Category: Chandrasekhar, S.]]
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[[Category: Chandrasekhar S]]
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[[Category: Chirgadze, N.Y.]]
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[[Category: Chirgadze NY]]
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[[Category: Clawson, D.K.]]
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[[Category: Clawson DK]]
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[[Category: Jin, L.]]
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[[Category: Jin L]]
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[[Category: Schevitz, R.W.]]
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[[Category: Schevitz RW]]
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[[Category: Smiley, D.L.]]
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[[Category: Smiley DL]]
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[[Category: Tashjian, A.H.]]
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[[Category: Tashjian AH]]
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[[Category: Zhang, F.]]
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[[Category: Zhang F]]
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[[Category: NA]]
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[[Category: helical dimer]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 16:46:32 2007''
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Current revision

CRYSTAL STRUCTURE OF HUMAN PARATHYROID HORMONE 1-34 AT 0.9 A RESOLUTION

PDB ID 1et1

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