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3may

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Current revision (08:47, 7 February 2024) (edit) (undo)
 
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<StructureSection load='3may' size='340' side='right'caption='[[3may]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='3may' size='340' side='right'caption='[[3may]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3may]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MAY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MAY FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3may]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MAY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MAY FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MT0213, Rv0203 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3may FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3may OCA], [https://pdbe.org/3may PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3may RCSB], [https://www.ebi.ac.uk/pdbsum/3may PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3may ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3may FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3may OCA], [https://pdbe.org/3may PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3may RCSB], [https://www.ebi.ac.uk/pdbsum/3may PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3may ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/O53654_MYCTO O53654_MYCTO]
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Mycobacterium tuberculosis must import iron from its host for survival, and its siderophore-dependent iron acquisition pathways are well established. Here we demonstrate a newly characterized pathway, whereby M. tuberculosis can use free heme and heme from hemoglobin as an iron source. Significantly, we identified the genomic region, Rv0202c-Rv0207c, responsible for the passage of heme iron across the mycobacterial membrane. Key players of this heme uptake system were characterized including a secreted protein and two transmembrane proteins, all three specific to mycobacteria. Furthermore, the crystal structure of the key heme carrier protein Rv0203 was found to have a unique fold. The discovery of a unique mycobacterial heme acquisition pathway opens new avenues of exploration into mycobacterial therapeutics.
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Discovery and characterization of a unique mycobacterial heme acquisition system.,Tullius MV, Harmston CA, Owens CP, Chim N, Morse RP, McMath LM, Iniguez A, Kimmey JM, Sawaya MR, Whitelegge JP, Horwitz MA, Goulding CW Proc Natl Acad Sci U S A. 2011 Mar 7. PMID:21383189<ref>PMID:21383189</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3may" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Chim, N]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Goulding, C W]]
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[[Category: Chim N]]
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[[Category: Helical protein]]
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[[Category: Goulding CW]]
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[[Category: Heme-binding protein]]
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Current revision

Crystal structure of a secreted Mycobacterium tuberculosis heme-binding protein

PDB ID 3may

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OCA

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